Ectopic lymphoid-like structures often develop at sites of inflammation where they influence
the course of infection, autoimmune disease, cancer and transplant rejection. These …

TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …

Objectives To unravel the hierarchy of cellular/molecular pathways in the disease tissue of
early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship …

RA is a heterogeneous clinical and pathobiological entity. Specific pathways within synovial
tissues are emerging as associated with diverse clinical evolution and therapeutic …

Clinical and experimental evidence suggest that interleukin-17A (IL-17A; also known as IL-
17) is an attractive therapeutic target in rheumatoid arthritis (RA). Rheumatoid synovial …

Background The etiology of rheumatoid arthritis (RA) remains poorly understood. Early and
accurate diagnosis still difficult to achieve. Inflammatory related molecules released into the …

Objectives Periodontitis and rheumatoid arthritis (RA) are two widespread chronic
inflammatory diseases with a previously suggested association. The objective of the current …

Osteoarthritis (OA) is the most common degenerative joint disease and the second leading
cause of disability worldwide. Single-omics analyses are far from elucidating the complex …

The TNF superfamily member TWEAK (TNFSF12) is a multifunctional cytokine implicated in
physiological tissue regeneration and wound repair. TWEAK is initially synthesized as a …

Introduction The immunoreceptor tyrosine-based activation motif (ITAM) pathway provides
osteoclast co-stimulatory signals and regulates proliferation, survival and differentiation of …