Glycosylation, and especially O-linked glycosylation, remains a critical blind spot in the
understanding of post-translational modifications. Due to their nature as proteins defined by …

Morphological transitions are typically attributed to the actions of proteins and lipids. Largely
overlooked in membrane shape regulation is the glycocalyx, a pericellular membrane coat …

The glycocalyx is a shell of heavily glycosylated proteins and lipids distributed on the cell
surface of nearly all cell types. Recently, it has been found that bulky transmembrane …

Inflammatory pathologies caused by phagocytes lead to numerous debilitating conditions,
including chronic pain and blindness due to age-related macular degeneration. Many …

Protein glycosylation, the attachment of sugars to amino acid side chains, can endow
proteins with a wide variety of properties of great interest to the engineering biology …

Mucins represent a largely untapped class of polymeric building block for biomaterials,
therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically …

One of the biggest challenges in modern chemistry is the preparation of synthetic materials
with life-like behavior for the assembly of artificial cells. In recent years, numerous artificial …

Antifreeze glycoproteins (AFGPs) are produced by extremophiles to defend against tissue
damage in freezing climates. Cumbersome isolation from polar fish has limited probing …

At the surface of many cells is a compendium of glycoconjugates that form an interface
between the cell and its surroundings; the glycocalyx. The glycocalyx serves several …

Cancer cell glycocalyx is a major line of defence against immune surveillance. However,
how specific physical properties of the glycocalyx are regulated on a molecular level …