Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment

X Yang, Q Li, W Liu, C Zong, L Wei, Y Shi… - Cellular & Molecular …, 2023 - nature.com
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or
hepatocellular carcinoma (HCC) and accounting for many deaths each year. The …

Mesenchymal stromal/stem cells and their extracellular vesicles in liver diseases: insights on their immunomodulatory roles and clinical applications

Q Huai, C Zhu, X Zhang, H Dai, X Li, H Wang - Cell & Bioscience, 2023 - Springer
Liver disease is a leading cause of mortality and morbidity that is rising globally. Liver
dysfunctions are classified into acute and chronic diseases. Various insults, including viral …

The develo** role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles

GGR Ortiz, NH Zaidi, RS Saini, AAR Coronel… - International …, 2023 - Elsevier
Autoimmune diseases are complex, chronic inflammatory conditions initiated by the loss of
immunological tolerance to self-antigens. Nowadays, there is no effective and useful therapy …

Unraveling the complexities of fibrosis and ductular reaction in liver disease: Pathogenesis, mechanisms, and therapeutic insights

C Marakovits, H Francis - American Journal of Physiology …, 2024 - journals.physiology.org
Ductular reaction and fibrosis are hallmarks of many liver diseases including primary
sclerosing cholangitis, primary biliary cholangitis, biliary atresia, alcoholic liver disease, and …

Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2−/− Mice and Human Intrahepatic …

Q Yao, W Chen, Y Yu, F Gao, J Zhou, J Wu, Q Pan… - Research, 2023 - spj.science.org
Primary sclerosing cholangitis (PSC) is a biliary disease accompanied by chronic
inflammation of the liver and biliary stricture. Mesenchymal stem cells (MSCs) are used to …

Serum metabonomics reveal the effectiveness of human placental mesenchymal stem cell therapy for primary sclerosing cholangitis

Y Yu, Q Yao, D Chen, Z Zhang, Q Pan, J Yu… - Stem Cell Research & …, 2024 - Springer
Background The metabolic patterns of human placental-derived mesenchymal stem cell (hP-
MSC) treatment for primary sclerosing cholangitis (PSC) remain unclear, and therapeutic …

Mesenchymal Stem Cell–Derived Exosomes in Various Chronic Liver Diseases: Hype or Hope?

L Zhu, Q Wang, M Guo, H Fang, T Li, Y Zhu… - Journal of …, 2024 - Taylor & Francis
Chronic liver conditions are associated with high mortality rates and have a large adverse
effect on human well-being as well as a significant financial burden. Currently, the only …

Emerging drugs for the treatment of primary sclerosing cholangitis

N Abbas, MN Quraishi, P Trivedi - Current opinion in pharmacology, 2022 - Elsevier
Primary sclerosing cholangitis (PSC) is a rare immune-mediated cholestatic disease for
which no medical therapy has been shown to slow disease progression. Consequently, liver …

hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/NF-κB signaling in an NMO mouse model

H Xu, W Jiang, X Li, J Jiang, SK Afridi, L Deng… - NPJ Regenerative …, 2024 - nature.com
Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disease of the central
nervous system that affects motor function and causes relapsing disability. Human umbilical …

Cutting edge issues in juvenile sclerosing cholangitis

A Di Giorgio, D Vergani, G Mieli-Vergani - Digestive and Liver Disease, 2022 - Elsevier
Sclerosing cholangitis (SC) is a rare chronic disorder characterised by inflammation and
progressive obliterative fibrosis of the intrahepatic and/or extrahepatic bile ducts. Diagnosis …