Protein evolution or engineering studies are traditionally focused on amino acid
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …

Alternative splicing (AS) is a widespread process underlying the generation of transcriptomic
and proteomic diversity and is frequently misregulated in human disease. Accordingly, an …

Alternative splicing (AS) patterns have diverged rapidly during vertebrate evolution, yet the
functions of most species-and lineage-specific splicing events are not known. We observe …

Tandem repetitions in protein sequence and structure is a fascinating subject of research
which has been a focus of study since the late 1990s. In this survey, we give an overview on …

Extracellular cytochromes are hypothesized to facilitate the final steps of electron transfer
between the outer membrane of the metal-reducing bacterium Geobacter sulfurreducens …

Genetic information often exhibits hierarchical and nested relationships, achieved through
the reuse of repetitive subsequences such as duplicons and transposable elements, a …

Repeats are ubiquitous elements of proteins and they play important roles for cellular
function and during evolution. Repeats are, however, also notoriously difficult to capture …

The aim of this study was to show that amino acid sequences have a latent periodicity with
insertions and deletions of amino acids in unknown positions of the analyzed sequence …

Recent interest in repeat proteins has arisen due to stable structural folds, high evolutionary
conservation and repertoire of functions provided by these proteins. However, repeat …

The review summarizes and systematizes the data on the classification, taxonomic
distribution, structural features, and functions of proteins with structural repeats. Modern …