CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …

Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a number
of host pathways to enable the viruses to persist. Persistence of human cytomegalovirus …

A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Interaction between gH/gL and the fusion protein gB is likely a conserved feature of the entry
mechanism for all herpesviruses. Human cytomegalovirus (HCMV) gH/gL can be bound by …

Human cytomegalovirus (HCMV) infection remains a major cause of morbidity in patient
populations. In certain clinical settings, it is the reactivation of the pre‐existing latent infection …

Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long
persistence in the host, like all herpesviruses, by way of a latent infection. During latency …

The transcriptional program associated with herpesvirus latency and the viral genes
regulating entry into and exit from latency are poorly understood and controversial. Here, we …

Viral persistence is the rule following infection with all herpesviruses. The β‐herpesvirus,
human cytomegalovirus (HCMV), persists through chronic and latent states of infection. Both …

Plasmacytoid dendritic cells (pDCs) can rapidly produce interferons and other soluble
factors in response to extracellular viruses or virus mimics such as CpG-containing DNA …

Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long
infections notably through the establishment of latency in hematopoietic stem cells (HSC) …