1.1. Background During exercise and with exposure to hot climatic conditions, there is
tendency for the human body to store heat and for body temperatures to rise. Changes in …

Vascular aging, a determinant factor for cardiovascular disease and health status in the
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …

In this review, we focus on significant developments in our understanding of the
mechanisms that control the cutaneous vasculature in humans, with emphasis on the …

CARDIOVASCULAR DISEASES affect 80 million people and are collectively the leading
cause of death in the United States (3). Impaired endothelial vascular signaling leading to …

This brief review is based on a President's Lecture presented at the Annual Meeting of the
American College of Sports Medicine in 2013. The purpose of this review is to assess the …

Passive heat therapy (repeated hot tub or sauna use) reduces cardiovascular risk, but its
effects on the mechanisms underlying improvements in microvascular function have yet to …

Vascular endothelial dysfunction is regarded as a primary phenotypic expression of normal
human aging. This senescence-induced disorder is the likely culprit underlying the …

Background Observational studies indicate that higher vitamin C intake is associated with
reduced risk for cardiovascular diseases. However, randomised controlled trials (RCT) …

Abstract Arginase (EC 3.5. 3.1) is the bimanganese enzyme that converts L‐arginine into
ornithine and urea. This enzyme was discovered more than a century ago and early α …

Ageing is associated with impaired endothelium‐derived nitric oxide (NO) function in human
microvessels. We investigated the impact of cardiorespiratory fitness and exercise training …