Feeding, which is essential for all animals, is regulated by homeostatic mechanisms. In
addition, food consumption is temporally coordinated by the brain over the circadian (~ 24 h) …

The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …

In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting
cues, adjusting internal∼ 24 h rhythms to resonate with, and anticipate, external cycles of …

REV-ERB nuclear receptors are potent transcriptional repressors that play an important role
in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its …

The circadian clock system in mammals plays a fundamental role in maintaining
homeostasis. Entrainment is an important characteristic of the internal clock, by which …

Orexins, or hypocretins, are excitatory neuropeptides involved in the regulation of feeding
behavior and the sleep and wakefulness states. Since their discovery, several lines of …

Evidence indicates that central regulation of food intake is well conserved along the
vertebrate lineage, at least between teleost fish and mammals. However, several differences …

The circadian clock regulates behavioural and physiological processes in a 24-h cycle. The
nuclear receptors REV-ERBα and REV-ERBβ are involved in the cell-autonomous circadian …

The food-entrainable oscillator (FEO) is a mysterious circadian clock because its anatomical
location (s) and molecular timekee** mechanism are unknown. Food anticipatory activity …

The circadian clock is an endogenous, time-tracking system that directs multiple metabolic
and physiological functions required for homeostasis. The master or central clock located …