Multiscale modeling meets machine learning: What can we learn?
Abstract Machine learning is increasingly recognized as a promising technology in the
biological, biomedical, and behavioral sciences. There can be no argument that this …
biological, biomedical, and behavioral sciences. There can be no argument that this …
Glia as sculptors of synaptic plasticity
Glial cells are non-neuronal cells in the nervous system that are crucial for proper brain
development and function. Three major classes of glia in the central nervous system (CNS) …
development and function. Three major classes of glia in the central nervous system (CNS) …
Sleep loss drives acetylcholine-and somatostatin interneuron–mediated gating of hippocampal activity to inhibit memory consolidation
Sleep loss disrupts consolidation of hippocampus-dependent memory. To characterize
effects of learning and sleep loss, we quantified activity-dependent phosphorylation of …
effects of learning and sleep loss, we quantified activity-dependent phosphorylation of …
Sleep, plasticity, and sensory neurodevelopment
A defining feature of early infancy is the immense neural plasticity that enables animals to
develop a brain that is functionally integrated with a growing body. Early infancy is also …
develop a brain that is functionally integrated with a growing body. Early infancy is also …
A mechanism for learning with sleep spindles
Spindles are ubiquitous oscillations during non-rapid eye movement (NREM) sleep. A
growing body of evidence points to a possible link with learning and memory, and the …
growing body of evidence points to a possible link with learning and memory, and the …
[HTML][HTML] The potential role of sleep in promoting a healthy body composition: underlying mechanisms determining muscle, fat, and bone mass and their association …
Sleep plays an essential role in human life. While sleep is a state elicited by the brain, its
vital role reaches beyond maintaining brain health. Unhealthy slee** habits have been …
vital role reaches beyond maintaining brain health. Unhealthy slee** habits have been …
Cell-type-specific dynamics of calcium activity in cortical circuits over the course of slow-wave sleep and rapid eye movement sleep
Sleep shapes cortical network activity, fostering global homeostatic downregulation of
excitability while maintaining or even upregulating excitability in selected networks in a …
excitability while maintaining or even upregulating excitability in selected networks in a …
How our understanding of memory replay evolves
Memory reactivations and replay, widely reported in the hippocampus and cortex across
species, have been implicated in memory consolidation, planning, and spatial and skill …
species, have been implicated in memory consolidation, planning, and spatial and skill …
Epilepsy and epileptiform activity in late-onset Alzheimer disease: Clinical and pathophysiological advances, gaps and conundrums
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …
Hippocampal neurons' cytosolic and membrane-bound ribosomal transcript profiles are differentially regulated by learning and subsequent sleep
The hippocampus is essential for consolidating transient experiences into long-lasting
memories. Memory consolidation is facilitated by postlearning sleep, although the …
memories. Memory consolidation is facilitated by postlearning sleep, although the …