Hepatotoxicity due to herbal dietary supplements: Past, present and the future

BJ Gurley, MR McGill, I Koturbash - Food and Chemical Toxicology, 2022 - Elsevier
Dietary supplements (DS) constitute a widely used group of products comprising vitamin,
mineral, and botanical extract formulations. DS of botanical or herbal origins (HDS) …

Recent advances in mass spectrometry (MS)-based glycoproteomics in complex biological samples

Z Chen, J Huang, L Li - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
Protein glycosylation plays a key role in various biological processes and disease-related
pathological progression. Mass spectrometry (MS)-based glycoproteomics is a powerful …

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)

K Hanaoka, T Ikeno, S Iwaki, S Deguchi… - Science …, 2024 - science.org
Various control strategies are available for building fluorogenic probes to visualize
biological events in terms of a fluorescence change. Here, we performed the time …

A drug screen using human iPSC-derived hepatocyte-like cells reveals cardiac glycosides as a potential treatment for hypercholesterolemia

MA Cayo, SK Mallanna, F Di Furio, R **g, LB Tolliver… - Cell Stem Cell, 2017 - cell.com
Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been
hampered by the lack of models. However, cells with hepatocyte characteristics can be …

Dynamic human liver proteome atlas reveals functional insights into disease pathways

L Niu, PE Geyer, R Gupta, A Santos… - Molecular Systems …, 2022 - embopress.org
Deeper understanding of liver pathophysiology would benefit from a comprehensive
quantitative proteome resource at cell type resolution to predict outcome and design …

Surfaceome map** of primary human heart cells with CellSurfer uncovers cardiomyocyte surface protein LSMEM2 and proteome dynamics in failing hearts

L Berg Luecke, M Waas, J Littrell… - Nature cardiovascular …, 2023 - nature.com
Cardiac cell surface proteins are drug targets and useful biomarkers for discriminating
among cellular phenotypes and disease states. Here we developed an analytical platform …

Decellularized human liver extracellular matrix (hDLM)‐mediated hepatic differentiation of human induced pluripotent stem cells (hIPSCs)

M Jaramillo, H Yeh, ML Yarmush… - Journal of tissue …, 2018 - Wiley Online Library
Liver tissue engineering has emerged as a promising approach in organ transplantation but
has been hampered by the lack of a reliable and readily available cell source. Human …

SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates

M Waas, ST Snarrenberg, J Littrell… - …, 2020 - academic.oup.com
Motivation Cell-type-specific surface proteins can be exploited as valuable markers for a
range of applications including immunophenoty** live cells, targeted drug delivery and in …

Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state

C Rogerson, E Britton, S Withey, N Hanley… - Genome …, 2019 - genome.cshlp.org
Esophageal adenocarcinoma (EAC) is one of the most frequent causes of cancer death, and
yet compared to other common cancers, we know relatively little about the molecular …

[HTML][HTML] In vitro differentiation of pluripotent stem cells into hepatocyte like cells–basic principles and current progress

N Graffmann, B Scherer, J Adjaye - Stem cell research, 2022 - Elsevier
Research in the field of hepatology is limited by the incomplete recapitulation of all major
aspects of human hepatic metabolism in most established models. This restricts our ability to …