The tetracycline antibiotics are known to be effective in the treatment of both infectious and
noninfectious disease conditions. The 16S rRNA binding mechanism currently held for the …

Chronic pain relief remains an unmet medical need. Current research points to a substantial
contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a …

Objective and design Chronic low-grade inflammation occurs in diabetic retinopathy (DR),
but the underlying mechanism (s) remains (remain) unclear. NLRP3 inflammasome …

The absence of selective pharmacological tools is a major barrier to the in vivo study of
microglia. To address this issue, we developed a G q-and G i-coupled Designer Receptor …

Minocycline is a second-generation, semi-synthetic tetracycline that has been in use in
therapy for over 30 years for its antibiotic properties against both Gram-positive and Gram …

One long standing aspect of microglia biology was never questioned; their involvement in
brain disease. Based on morphological changes (retracted processes and amoeboid shape) …

Myeloid cells of the central nervous system (CNS), which include parenchymal microglia,
macrophages at CNS interfaces and monocytes recruited from the circulation during …

To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal
models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and …

To test whether depletion of microglia in the optic nerve head has a beneficial effect on
retinal ganglion cell numbers and function, we depleted microglia by oral administration of …

Glycogen synthase kinase 3β (GSK3β) has been shown to be a crucial mediator of the
intensity and direction of the innate immune system response to bacterial stimuli. This review …