Thiazole: A promising heterocycle for the development of potent CNS active agents
Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to
display a variety of biological activities. Thiazole and its derivatives have attracted …
display a variety of biological activities. Thiazole and its derivatives have attracted …
An update on small molecule strategies targeting leishmaniasis
Leishmaniasis is an infectious disease caused by various species of protozoan parasite
known as Leishmania, which is transmitted to its mammalian host via bite of an infected …
known as Leishmania, which is transmitted to its mammalian host via bite of an infected …
Cyclohexane-1, 3-dione derivatives as future therapeutic agents for NSCLC: QSAR modeling, in silico ADME-Tox properties, and structure-based drug designing …
The abnormal expression of the c-Met tyrosine kinase has been linked to the proliferation of
several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this …
several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this …
Design, molecular docking analysis of an anti-inflammatory drug, computational analysis and intermolecular interactions energy studies of 1-benzothiophene-2 …
A Sagaama, N Issaoui - Computational biology and chemistry, 2020 - Elsevier
In this paper, theoretical study on molecular geometry, vibrational, pharmaceutical and
electronic properties of the monomeric and dimeric structures of 1-benzothiophene-2 …
electronic properties of the monomeric and dimeric structures of 1-benzothiophene-2 …
Synthesis and anti-microbial studies of new series of 1, 2, 3, 4-tetrazole integrated thieno [2, 3-d] pyrimidine derivatives
B Nagaraju, M Rajeswari, T Mounika, G Rajitha… - Journal of Molecular …, 2024 - Elsevier
The present study describes synthesis of a novel series of 1, 2, 3, 4-tetrazole integrated
thieno [2, 3-d]-pyrimidine hybrid 11a-l. Further, in vitro anti-microbial activities of the …
thieno [2, 3-d]-pyrimidine hybrid 11a-l. Further, in vitro anti-microbial activities of the …
Cytotoxic effects, carbonic anhydrase isoenzymes, α-glycosidase and acetylcholinesterase inhibitory properties, and molecular docking studies of heteroatom …
Today, interest in studies on the search for new drugs to be used in diseases such as
cancer, cardiovascular diseases, neurodegenerative diseases and diabetes, as well as …
cancer, cardiovascular diseases, neurodegenerative diseases and diabetes, as well as …
2-Amino-thiophene derivatives present antileishmanial activity mediated by apoptosis and immunomodulation in vitro
KA da Franca Rodrigues, CN de Sousa Dias… - European journal of …, 2015 - Elsevier
This study evaluated the effects of 2-amino-thiophene derivatives on the promastigote and
amastigote forms of Leishmania (Leishmania) amazonensis and their possible mechanisms …
amastigote forms of Leishmania (Leishmania) amazonensis and their possible mechanisms …
3D computer modeling of inhibitors targeting the MCF-7 breast cancer cell line
This study focused on develo** new inhibitors for the MCF-7 cell line to contribute to our
understanding of breast cancer biology and various experimental techniques. 3D QSAR …
understanding of breast cancer biology and various experimental techniques. 3D QSAR …
Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidine derivatives
SE Abbas, NMA Gawad, RF George, YA Akar - European Journal of …, 2013 - Elsevier
Two series of new tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidines namely 2, 3-
disubstituted derivatives 3a–z and 2, 4-disubstituted ones 6a–c were prepared and tested …
disubstituted derivatives 3a–z and 2, 4-disubstituted ones 6a–c were prepared and tested …
Pocket-based lead optimization strategy for the design and synthesis of chitinase inhibitors
Y Dong, S Hu, X Jiang, T Liu, Y Ling, X He… - Journal of agricultural …, 2019 - ACS Publications
Insect chitinases play an indispensable role in shedding old cuticle during molting.
Targeting chitinase inhibition is a promising pest control strategy. Of ChtI, a chitinase from …
Targeting chitinase inhibition is a promising pest control strategy. Of ChtI, a chitinase from …