Metalloproteins catalyse some of the most complex and important processes in nature, such
as photosynthesis and water oxidation. An ultimate test of our knowledge of how …

Zinc is an essential element required for the function of more than 300 enzymes spanning all
classes. Despite years of dedicated study, questions regarding the connections between …

Computationally designing protein–protein interactions with high affinity and desired
orientation is a challenging task. Incorporating metal-binding sites at the target interface may …

Nature provides inspiration for designing materials and systems that derive their functions
from highly organized structures. Biological hard tissues are hybrid materials having …

Motivation: A large number of proteins contain metal ions that are essential for their stability
and biological activity. Identifying and characterizing metal-binding sites through …

Metal ions are vital components in many proteins for the inference and engineering of
protein function, with coordination complexity linked to structural (4-residue predominate) …

Motivation: Zinc-binding proteins are the most abundant metallo-proteins in Protein Data
Bank (PDB). Accurate prediction of zinc-binding sites in proteins of unknown function may …

The number of metal-containing waste streams resulting from electronic end-of life products,
metallurgical by-products, and mine tailings to name but a few, is increasing worldwide. In …

Zinc-binding proteins are the most abundant metalloproteins in the Protein Data Bank where
the zinc ions usually have catalytic, regulatory or structural roles critical for the function of the …

Myoglobins provide an opportunity to investigate the effect of the secondary coordination
sphere on the functionality and reactivity of non-native metal porphyrins inside well-defined …