Chlorinated paraffins (CPs), a group of chlorinated alkane mixtures, are frequently detected
in various environmental matrices and human bodies. Recently, CPs have garnered …

Lipids are essential molecules that play key roles in cell physiology by serving as structural
components, for storage of energy, and in signal transduction. Hence, efficient regulation …

Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …

Chronic stress–induced epinephrine (EPI) accelerates breast cancer progression and
metastasis, but the molecular mechanisms remain unclear. Herein, we found a strong …

Background & Aims As a nicotinamide adenine dinucleotide-dependent deacetylase and a
key epigenetic regulator, sirtuin 6 (SIRT6) has been implicated in the regulation of …

Conclusions These data indicate that RNF5 inhibits NASH progression by targeting HRD1 in
the ubiquitin‐mediated proteasomal pathway. Targeting the RNF5–HRD1 axis may provide …

Hepatocellular carcinoma (HCC), also known as hepatoma, is a primary malignancy of the
liver and the third leading cause of cancer mortality globally. Although much attention has …

The recent literature has revolutionized our view on the vital importance of endoplasmic
reticulum (ER)-associated degradation (ERAD) in health and disease. Suppressor/enhancer …

Accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) lumen
triggers an unfolded protein response (UPR) for stress adaptation, the failure of which …

Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic
reprogramming and plays a crucial role in the occurrence and development of tumours …