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Kisspeptins and reproduction: physiological roles and regulatory mechanisms
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …
have evolved to mediate the diverse internal and external environmental inputs that regulate …
Kisspeptin signaling in the brain
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B
Kisspeptin is a potent stimulator of GnRH secretion that has been implicated in the feedback
actions of ovarian steroids. In ewes, the majority of hypothalamic kisspeptin neurons are …
actions of ovarian steroids. In ewes, the majority of hypothalamic kisspeptin neurons are …
Kisspeptin–GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge
Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in
the neural control of fertility in animal models and humans. The gonadotropin-releasing …
the neural control of fertility in animal models and humans. The gonadotropin-releasing …
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
Neurons that produce gonadotropin-releasing hormone (GnRH) are the final common
pathway by which the brain regulates reproduction. GnRH neurons are regulated by an …
pathway by which the brain regulates reproduction. GnRH neurons are regulated by an …
Distribution of kisspeptin neurones in the adult female mouse brain
Kisspeptin‐GPR54 signalling is essential for normal reproductive functioning. However, the
distribution of kisspeptin neuronal cell bodies and their projections is not well established …
distribution of kisspeptin neuronal cell bodies and their projections is not well established …
New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
Identification, in late 2003, of inactivating mutations of the G protein-coupled receptor
GPR54 as causative factor for absence of puberty and hypogonadotropic hypogonadism in …
GPR54 as causative factor for absence of puberty and hypogonadotropic hypogonadism in …
Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel …
Reproductive activity in sheep is seasonal, being activated by short-day photoperiods and
inhibited by long days. During the nonbreeding season, GnRH secretion is reduced by both …
inhibited by long days. During the nonbreeding season, GnRH secretion is reduced by both …
Influence of photoperiod on hormones, behavior, and immune function
Photoperiodism is the ability of plants and animals to measure environmental day length to
ascertain time of year. Central to the evolution of photoperiodism in animals is the adaptive …
ascertain time of year. Central to the evolution of photoperiodism in animals is the adaptive …
The role of kisspeptin signaling in reproduction
Kisspeptins are a group of peptides that stimulate GnRH release and are required for
puberty and maintenance of normal reproductive function. This review focuses on our …
puberty and maintenance of normal reproductive function. This review focuses on our …