Training deep neural density estimators to identify mechanistic models of neural dynamics

PJ Gonçalves, JM Lueckmann, M Deistler… - Elife, 2020 - elifesciences.org
Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of
underlying causes. However, determining which model parameters agree with complex and …

Spike sorting algorithms and their efficient hardware implementation: a comprehensive survey

T Zhang, MR Azghadi, C Lammie… - Journal of Neural …, 2023 - iopscience.iop.org
Objective. Spike sorting is a set of techniques used to analyze extracellular neural
recordings, attributing individual spikes to individual neurons. This field has gained …

Recurrent neural networks with explicit representation of dynamic latent variables can mimic behavioral patterns in a physical inference task

R Rajalingham, A Piccato, M Jazayeri - Nature Communications, 2022 - nature.com
Primates can richly parse sensory inputs to infer latent information. This ability is
hypothesized to rely on establishing mental models of the external world and running mental …

Estimating transfer entropy in continuous time between neural spike trains or other event-based data

DP Shorten, RE Spinney, JT Lizier - PLoS computational biology, 2021 - journals.plos.org
Transfer entropy (TE) is a widely used measure of directed information flows in a number of
domains including neuroscience. Many real-world time series for which we are interested in …

Interrogating theoretical models of neural computation with emergent property inference

SR Bittner, A Palmigiano, AT Piet, CA Duan, CD Brody… - Elife, 2021 - elifesciences.org
A cornerstone of theoretical neuroscience is the circuit model: a system of equations that
captures a hypothesized neural mechanism. Such models are valuable when they give rise …

Learning non-stationary Langevin dynamics from stochastic observations of latent trajectories

M Genkin, O Hughes, TA Engel - Nature communications, 2021 - nature.com
Many complex systems operating far from the equilibrium exhibit stochastic dynamics that
can be described by a Langevin equation. Inferring Langevin equations from data can …

Deep inverse modeling reveals dynamic-dependent invariances in neural circuit mechanisms

R Gao, M Deistler, A Schulz, PJ Gonçalves, JH Macke - Biorxiv, 2024 - biorxiv.org
Neural population dynamics are shaped by many cellular, synaptic, and network properties.
Not only is it important to understand how coordinated changes in circuit parameters alter …

Circumstantial evidence and explanatory models for synapses in large-scale spike recordings

IH Stevenson - arxiv preprint arxiv:2304.09699, 2023 - arxiv.org
Whether, when, and how causal interactions between neurons can be meaningfully studied
from observations of neural activity alone are vital questions in neural data analysis. Here …

Resting-state neural firing rate is linked to cardiac-cycle duration in the human cingulate and parahippocampal cortices

K Kim, J Ladenbauer, M Babo-Rebelo… - Journal of …, 2019 - Soc Neuroscience
Stimulation and functional imaging studies have revealed the existence of a large network of
cortical regions involved in the regulation of heart rate. However, very little is known about …

Model-based detection of putative synaptic connections from spike recordings with latency and type constraints

N Ren, S Ito, H Hafizi, JM Beggs… - Journal of …, 2020 - journals.physiology.org
Detecting synaptic connections using large-scale extracellular spike recordings presents a
statistical challenge. Although previous methods often treat the detection of each putative …