Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide
future therapeutic strategies to modulate the disease progression. The current paradigm of …

Background Osteoarthritis is the most common joint disease of adults worldwide. Its
incidence rises with age. Both intrinsic and extrinsic risk factors promote its development. In …

Background The effectiveness of platelet-rich plasma (PRP) injections for osteoarthritis (OA)
is still controversial. We investigated the effect of PRP injections in patients with knee OA …

Background: Currently, there are limited nonoperative treatment options available for knee
osteoarthritis (OA). Cell-based therapies have emerged as promising treatments for knee …

Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most
common diseases worldwide. Its prevalence and severity are increasing owing to aging of …

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a
chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its …

OBJECTIVE: Osteoarthritis (OA) is prevalent and difficult to treat. Autologous conditioned
serum (ACS), marketed under the trade name Orthokine, is a novel, injectable antiarthritic …

Purpose Bone marrow concentrate (BMC) and platelet-rich plasma (PRP) are used
extensively in regenerative medicine. The aim of this study was to determine differences in …

Osteoarthritis is a painful, chronic disease with widespread burden on patients,
communities, health and social care systems. Conservative therapies, such as …

Introduction AMG 108 is a fully human, immunoglobulin subclass G2 (IgG2) monoclonal
antibody that binds the human interleukin-1 (IL-1) receptor type 1, inhibiting the activity of IL …