Melatonin in cancer treatment: current knowledge and future opportunities

WH Talib, AR Alsayed, A Abuawad, S Daoud… - Molecules, 2021 - mdpi.com
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

Clinical translation of advanced colonic drug delivery technologies

A Awad, CM Madla, LE McCoubrey, F Ferraro… - Advanced drug delivery …, 2022 - Elsevier
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local
diseases, direct access to unique therapeutic targets and the potential for increasing …

Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy

A Mafi, M Rezaee, N Hedayati, SD Hogan… - Cell Communication and …, 2023 - Springer
Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

Exploring the mechanical perspective of a new anti-tumor agent: melatonin

S Rohilla, M Singh, S Priya, WH Almalki… - Journal of …, 2023 - dl.begellhouse.com
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: a therapeutic target to reduce intestinal inflammation

N Ma, J Zhang, RJ Reiter, X Ma - Medicinal Research Reviews, 2020 - Wiley Online Library
Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm
regulation and sleep aiding, has shown its potential as a co‐adjuvant treatment in intestinal …

Melatonin enhances radiofrequency-induced NK antitumor immunity, causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor …

M Li, B Hao, M Zhang, RJ Reiter, S Lin… - … and Targeted Therapy, 2021 - nature.com
Surgery is the common treatment for early lung cancer with multiple pulmonary nodules, but
it is often accompanied by the problem of significant malignancy of other nodules in non …

Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis

RJ Reiter, R Sharma, Q Ma, S Rorsales-Corral… - Cellular and Molecular …, 2020 - Springer
Melatonin has the ability to intervene in the initiation, progression and metastasis of some
experimental cancers. A large variety of potential mechanisms have been advanced to …

Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases

AI Socaciu, R Ionuţ, MA Socaciu, AP Ungur… - Reviews in Endocrine …, 2020 - Springer
The last four decades, we assist to an increasing scientific interest on melatonin, a circadian
hormone, a metabolic regulator which influences not only plants' metabolism and their …

Melatonin regulates tumor angiogenesis via miR-424-5p/VEGFA signaling pathway in osteosarcoma

S Vimalraj, S Saravanan, S Raghunandhakumar… - Life Sciences, 2020 - Elsevier
Melatonin is recognized as an anti-angiogenic agent, but its function in the tumor
microenvironment especially in osteosarcoma remains uncertain. Among the selected …

Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways

T Gao, T Wang, Z Wang, J Cao, Y Dong… - International …, 2021 - Elsevier
Background Inflammatory bowel disease (IBD) is an inflammatory response relative chronic
disease in the intestinal tract. Our previous study demonstrated melatonin exerts an …