Background Chronic and/or extreme stress in early life, often referred to as early adversity,
childhood trauma, or early life stress, has been associated with a wide range of adverse …

Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Discovering the processes through which early adverse experiences affect children's
nervous-system development, health, and behavior is critically important for develo** …

The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …

The global burden of early life adversity (ELA) is profound. The World Health Organization
has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to …

Human brain development is influenced by early-life experiences, particularly during
sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the …

Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

Maternal care is a critical determinant of child development. However, our understanding of
processes and mechanisms by which maternal behavior influences the develo** human …

Background Anhedonia, the diminished ability to experience pleasure, is an important
dimensional entity linked to depression, schizophrenia, and other emotional disorders, but …

A contemporary model for the pathogenesis of mood disorders (bipolar and depressive
disorders) involves gene-environmental interaction, with genetic predisposition, epigenetic …