[HTML][HTML] Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them

MT Sorbara, EG Pamer - Mucosal immunology, 2019 - Elsevier
The communities of bacteria that reside in the intestinal tract are in constant competition
within this dynamic and densely colonized environment. At homeostasis, the equilibrium that …

Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications

F Steffen-Munsberg, C Vickers, H Kohls, H Land… - Biotechnology …, 2015 - Elsevier
In this review we analyse structure/sequence–function relationships for the superfamily of
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …

Exceptional peroxidase-like activity of an iron and copper based organic framework nanosheet for consecutive colorimetric biosensing of glucose and kanamycin in …

R Jesuraj, A Amalraj, VK Vaidyanathan, P Perumal - Analyst, 2023 - pubs.rsc.org
Two-dimensional metal–organic framework nanosheets are attractive as peroxidase
mimicking nanocatalysts due to their rich chemical functional groups, large surface area …

Metabolite–enzyme coevolution: from single enzymes to metabolic pathways and networks

L Noda-Garcia, W Liebermeister… - Annual Review of …, 2018 - annualreviews.org
How individual enzymes evolved is relatively well understood. However, individual enzymes
rarely confer a physiological advantage on their own. Judging by its current state, the …

Streptomycetes: surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products

KK Nepal, G Wang - Biotechnology advances, 2019 - Elsevier
Due to the worldwide prevalence of multidrug-resistant pathogens and high incidence of
diseases such as cancer, there is an urgent need for the discovery and development of new …

Streptomyces venezuelae TX‐TL – a next generation cell‐free synthetic biology tool

SJ Moore, HE Lai, H Needham, KM Polizzi… - Biotechnology …, 2017 - Wiley Online Library
Streptomyces venezuelae is a promising chassis in synthetic biology for fine chemical and
secondary metabolite pathway engineering. The potential of S. venezuelae could be further …

Synthetic biological approaches to natural product biosynthesis

JM Winter, Y Tang - Current opinion in biotechnology, 2012 - Elsevier
Small molecules produced in Nature possess exquisite chemical diversity and continue to
be an inspiration for the development of new therapeutic agents. In their host organisms …

Multiplex lateral flow immunoassay for five antibiotics detection based on gold nanoparticle aggregations

J Peng, Y Wang, L Liu, H Kuang, A Li, C Xu - RSC advances, 2016 - pubs.rsc.org
A new immunochromatographic assay (ICA) was developed for the simultaneous screening
of five antibiotics that can coexist in milk, namely lincomycin (LIN), gentamicin (GEN) …

Cell‐free exploration of the natural product chemical space

JW Bogart, MD Cabezas, B Vögeli, DA Wong… - …, 2021 - Wiley Online Library
Natural products and secondary metabolites comprise an indispensable resource from living
organisms that have transformed areas of medicine, agriculture, and biotechnology. Recent …

Delineating the biosynthesis of gentamicin X2, the common precursor of the gentamicin C antibiotic complex

C Huang, F Huang, E Moison, J Guo, X Jian, X Duan… - Chemistry & Biology, 2015 - cell.com
Gentamicin C complex is a mixture of aminoglycoside antibiotics used worldwide to treat
severe Gram-negative bacterial infections. Despite its clinical importance, the enzymology of …