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[HTML][HTML] Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them
The communities of bacteria that reside in the intestinal tract are in constant competition
within this dynamic and densely colonized environment. At homeostasis, the equilibrium that …
within this dynamic and densely colonized environment. At homeostasis, the equilibrium that …
Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
F Steffen-Munsberg, C Vickers, H Kohls, H Land… - Biotechnology …, 2015 - Elsevier
In this review we analyse structure/sequence–function relationships for the superfamily of
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …
Exceptional peroxidase-like activity of an iron and copper based organic framework nanosheet for consecutive colorimetric biosensing of glucose and kanamycin in …
Two-dimensional metal–organic framework nanosheets are attractive as peroxidase
mimicking nanocatalysts due to their rich chemical functional groups, large surface area …
mimicking nanocatalysts due to their rich chemical functional groups, large surface area …
Metabolite–enzyme coevolution: from single enzymes to metabolic pathways and networks
How individual enzymes evolved is relatively well understood. However, individual enzymes
rarely confer a physiological advantage on their own. Judging by its current state, the …
rarely confer a physiological advantage on their own. Judging by its current state, the …
Streptomycetes: surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products
KK Nepal, G Wang - Biotechnology advances, 2019 - Elsevier
Due to the worldwide prevalence of multidrug-resistant pathogens and high incidence of
diseases such as cancer, there is an urgent need for the discovery and development of new …
diseases such as cancer, there is an urgent need for the discovery and development of new …
Streptomyces venezuelae TX‐TL – a next generation cell‐free synthetic biology tool
Streptomyces venezuelae is a promising chassis in synthetic biology for fine chemical and
secondary metabolite pathway engineering. The potential of S. venezuelae could be further …
secondary metabolite pathway engineering. The potential of S. venezuelae could be further …
Synthetic biological approaches to natural product biosynthesis
Small molecules produced in Nature possess exquisite chemical diversity and continue to
be an inspiration for the development of new therapeutic agents. In their host organisms …
be an inspiration for the development of new therapeutic agents. In their host organisms …
Multiplex lateral flow immunoassay for five antibiotics detection based on gold nanoparticle aggregations
A new immunochromatographic assay (ICA) was developed for the simultaneous screening
of five antibiotics that can coexist in milk, namely lincomycin (LIN), gentamicin (GEN) …
of five antibiotics that can coexist in milk, namely lincomycin (LIN), gentamicin (GEN) …
Cell‐free exploration of the natural product chemical space
Natural products and secondary metabolites comprise an indispensable resource from living
organisms that have transformed areas of medicine, agriculture, and biotechnology. Recent …
organisms that have transformed areas of medicine, agriculture, and biotechnology. Recent …
Delineating the biosynthesis of gentamicin X2, the common precursor of the gentamicin C antibiotic complex
Gentamicin C complex is a mixture of aminoglycoside antibiotics used worldwide to treat
severe Gram-negative bacterial infections. Despite its clinical importance, the enzymology of …
severe Gram-negative bacterial infections. Despite its clinical importance, the enzymology of …