Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes
to the development of pain hypersensitivity. How activated microglia selectively enhance the …

Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …

Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

The extracellular matrix (ECM) is known to regulate important processes in neuronal cell
development, activity and growth. It is associated with the structural stabilization of neuronal …

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here
we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via …

Diseases and injuries of the central nervous system (CNS) including those in the brain,
spinal cord and retina are devastating because the CNS has limited intrinsic regenerative …

Transplantation of Schwann cells (SCs) is a promising therapeutic strategy for spinal cord
repair. SCs introduced into lesions support axon regeneration, but because these axons do …

Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central
nervous system, serving as guidance cues during development and modulating synaptic …