Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis
Background There is conflicting evidence, relying on heterogeneous studies, as to whether
aldosterone excess is responsible for an increased risk of cardiovascular and …
aldosterone excess is responsible for an increased risk of cardiovascular and …
Role of the renin-angiotensin-aldosterone system beyond blood pressure regulation: molecular and cellular mechanisms involved in end-organ damage during …
Arterial hypertension is a common condition worldwide and an important predictor of several
complicated diseases. Arterial hypertension can be triggered by many factors, including …
complicated diseases. Arterial hypertension can be triggered by many factors, including …
[HTML][HTML] Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies
According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …
general and cardiovascular disease (CVD) in particular are the leading cause of premature …
Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis
Chronic kidney disease (CKD) represents a global health concern, and its prevalence is
increasing. The ultimate therapeutic option for CKD is kidney transplantation. However, the …
increasing. The ultimate therapeutic option for CKD is kidney transplantation. However, the …
Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis
NJ Brown - Nature Reviews Nephrology, 2013 - nature.com
The steroid hormone aldosterone regulates sodium and potassium homeostasis.
Aldosterone and activation of the mineralocorticoid receptor also causes inflammation and …
Aldosterone and activation of the mineralocorticoid receptor also causes inflammation and …
The effect of aldosterone on cardiorenal and metabolic systems
Aldosterone, a vital hormone of the human body, has various pathophysiological roles. The
excess of aldosterone, also known as primary aldosteronism, is the most common …
excess of aldosterone, also known as primary aldosteronism, is the most common …
Glucocorticoids and cardiovascular disease
Chronic excessive activation of glucocorticoid receptors induces obesity, insulin resistance,
glucose intolerance, dyslipidaemia and hypertension. Subtle abnormalities of the …
glucose intolerance, dyslipidaemia and hypertension. Subtle abnormalities of the …
HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis
High-density lipoprotein (HDL) has been identified as a potential target in the treatment of
atherosclerotic vascular disease. The failure of torcetrapib, an inhibitor of cholesteryl ester …
atherosclerotic vascular disease. The failure of torcetrapib, an inhibitor of cholesteryl ester …
T regulatory lymphocytes prevent aldosterone-induced vascular injury
Aldosterone mediates actions of the renin-angiotensin-aldosterone system inducing
hypertension, oxidative stress, and vascular inflammation. Recently, we showed that …
hypertension, oxidative stress, and vascular inflammation. Recently, we showed that …
NADPH oxidases in cardiovascular disease
Reactive oxygen species (ROS) contribute to several aspects of vascular diseases including
ischemia–reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and …
ischemia–reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and …