The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

RAS mutation is the most frequent oncogenic alteration in human cancers. KRAS is the most
frequently mutated followed by NRAS. The emblematic KRAS mutant cancers are …

Background High tumor mutation burden (TMB) can benefit immunotherapy for multiple
tumor types, but the prevalence of hypermutated breast cancer is not well described. The …

Cancer cells accumulate many genetic alterations throughout their lifetime, but only a few of
them drive cancer progression, termed driver mutations. Driver mutations may vary between …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

Purpose: The incidence rates of colorectal cancers are increasing in young adults. The
objective of this study was to investigate genomic differences between tumor samples …

Simple Summary Organometallics, such as copper compounds, are cancer
chemotherapeutics used alone or in combination with other drugs. One small group of …

Background Somatic mutations in healthy tissues contribute to aging, neurodegeneration,
and cancer initiation, yet they remain largely uncharacterized. Results To gain a better …

KRAS is the most frequently mutated oncogene in cancer, yet there is little understanding of
how specific KRAS amino acid changes affect tumor initiation, progression, or therapy …

Xeroderma pigmentosum (XP) is a genetic disorder caused by mutations in genes of the
Nucleotide Excision Repair (NER) pathway (groups AG) or in Translesion Synthesis DNA …