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Innate immunity in the middle ear mucosa
Otitis media (OM) encompasses a spectrum of clinical presentations ranging from the readily
identifiable Acute OM (AOM), which is characterised by otalgia and fever, to chronic otitis …
identifiable Acute OM (AOM), which is characterised by otalgia and fever, to chronic otitis …
ISOM 2023 research Panel 4-Diagnostics and microbiology of otitis media
Objectives To identify and review key research advances from the literature published
between 2019 and 2023 on the diagnosis and microbiology of otitis media (OM) including …
between 2019 and 2023 on the diagnosis and microbiology of otitis media (OM) including …
Case-control microbiome study of chronic otitis media with effusion in children points at streptococcus salivarius as a pathobiont-inhibiting species
Chronic otitis media with effusion (OME) has been associated with a shift in microbiome
composition and microbial interaction in the upper respiratory tract (URT). While most …
composition and microbial interaction in the upper respiratory tract (URT). While most …
Role of cytokines and Th17/Tregs imbalance in the pathogenesis of otitis media with effusion. Modulation of Notch1/Hes1/mTORC1/S6k1 signalling pathway underlies …
Otitis media with effusion (OME) is a recurrent middle ear inflammatory condition. It may be
complicated by acquired hearing loss and speech impairment especially in children …
complicated by acquired hearing loss and speech impairment especially in children …
Otitis media: Interactions between host and environment, immune and inflammatory responses
J Nokso-Koivisto, GD Ehrlich, F Enoksson… - International journal of …, 2024 - Elsevier
Objective To review and highlight progress in otitis media (OM) research in the areas of
immunology, inflammation, environmental influences and host-pathogen responses from …
immunology, inflammation, environmental influences and host-pathogen responses from …
Characterization of middle ear microbiome in otitis media with effusion in Hungarian children: Alloiococcus otitidis may potentially hamper the microbial diversity
Introduction Although otitis media with effusion (OME) is a common cause of hearing
impairment in children, little is known about its microbiological background. We aimed to …
impairment in children, little is known about its microbiological background. We aimed to …
PANEL 3: otitis media animal models, cell culture, tissue regeneration & pathophysiology
Objective To review and summarize recently published key articles on the topics of animal
models, cell culture studies, tissue biomedical engineering and regeneration, and new …
models, cell culture studies, tissue biomedical engineering and regeneration, and new …
Nasopharyngeal microbiome composition associated with Streptococcus pneumoniae colonization suggests a protective role of Corynebacterium in young children
L Xu, J Earl, ME Pichichero - PLoS One, 2021 - journals.plos.org
Streptococcus pneumoniae (Spn) is a leading respiratory tract pathogen that colonizes the
nasopharynx (NP) through adhesion to epithelial cells and immune evasion. Spn actively …
nasopharynx (NP) through adhesion to epithelial cells and immune evasion. Spn actively …
Corynebacteria from the respiratory microbiota modulate inflammatory responses and associate with a reduced pneumococcal burden in the lungs
C Bergenfelz, P Do, L Larsson, H Ivarsson… - Frontiers in Cellular …, 2025 - frontiersin.org
Background Certain species from the normal respiratory tract microbiota have recently been
proposed to positively influence human health. Corynebacterium propinquum and C …
proposed to positively influence human health. Corynebacterium propinquum and C …
Nasopharyngeal microbiome analyses in otitis-prone and otitis-free children
L Xu, J Earl, P Bajorski, E Gonzalez… - International Journal of …, 2021 - Elsevier
Abstract Objectives About 10–15% children develop frequent acute otitis media (AOM)
confirmed by tympanocentesis. These children are designated sOP (stringently defined otitis …
confirmed by tympanocentesis. These children are designated sOP (stringently defined otitis …