Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the
generation of induced pluripotent stem cells, have delivered preliminary evidence that …

CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology
and entered the clinical world for targeted gene therapy. Identifying DNA modifications …

Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

The encapsulation of stem cells in a hydrogel substrate provides a promising future in
biomedical applications. However, communications between hydrogels and stem cells is …

Transposable elements (TEs) regulate diverse biological processes, from early development
to cancer. Expression of young TEs is difficult to measure with next-generation, single-cell …

Despite often being classified as selfish or junk DNA, transposable elements (TEs) are a
group of abundant genetic sequences that have a significant impact on mammalian …

DNA mutations as a consequence of errors during DNA damage repair, replication, or
mitosis are the substrate for evolution. In multicellular organisms, mutations can occur in the …

Half the human genome is made of transposable elements (TEs), whose ongoing activity
continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon …