Kir channel molecular physiology, pharmacology, and therapeutic implications
M Cui, L Cantwell, A Zorn, DE Logothetis - Pharmacology of Potassium …, 2021 - Springer
For the past two decades several scholarly reviews have appeared on the inwardly rectifying
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …
The roles of Gβγ and Gα in gating and regulation of GIRK channels
N Dascal, U Kahanovitch - International review of neurobiology, 2015 - Elsevier
Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …
A molecular switch controls the impact of cholesterol on a Kir channel
Cholesterol decreases the activity of the majority of ion channels while increasing the activity
of only a few, yet it remains unclear how. Here, we used the inwardly rectifying potassium …
of only a few, yet it remains unclear how. Here, we used the inwardly rectifying potassium …
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating
VN Bavro, R De Zorzi, MR Schmidt… - Nature structural & …, 2012 - nature.com
KirBac channels are prokaryotic homologs of mammalian inwardly rectifying (Kir) potassium
channels, and recent crystal structures of both Kir and KirBac channels have provided major …
channels, and recent crystal structures of both Kir and KirBac channels have provided major …
Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels
Anionic phospholipids are critical constituents of the inner leaflet of the plasma membrane,
ensuring appropriate membrane topology of transmembrane proteins. Additionally, in …
ensuring appropriate membrane topology of transmembrane proteins. Additionally, in …
[PDF][PDF] Regulation of ion channels by membrane lipids
A Rosenhouse-Dantsker, D Mehta, I Levitan - Compr Physiol, 2012 - researchgate.net
The major membrane lipid regulators of ion channel function include cholesterol, one of the
main lipid components of the plasma membranes, phosphoinositides, a group of regulatory …
main lipid components of the plasma membranes, phosphoinositides, a group of regulatory …
On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer
G protein–gated inwardly rectifying K+(GIRK) channels belong to the inward-rectifier K+(Kir)
family, are abundantly expressed in the heart and the brain, and require that …
family, are abundantly expressed in the heart and the brain, and require that …
Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus
Hypercholesterolemia is a well known risk factor for the development of neurodegenerative
disease. However, the underlying mechanisms are mostly unknown. In recent years, it has …
disease. However, the underlying mechanisms are mostly unknown. In recent years, it has …
Endocannabinoid regulation of inward rectifier potassium (Kir) channels
S Mayar, M Borbuliak, A Zoumpoulakis… - Frontiers in …, 2024 - frontiersin.org
The inward rectifier potassium channel Kir2. 1 (KCNJ2) is an important regulator of resting
membrane potential in both excitable and non-excitable cells. The functions of Kir2. 1 …
membrane potential in both excitable and non-excitable cells. The functions of Kir2. 1 …
The molecular mechanism by which PIP2 opens the intracellular G-loop gate of a Kir3. 1 channel
Inwardly rectifying potassium (Kir) channels are characterized by a long pore comprised of
continuous transmembrane and cytosolic portions. A high-resolution structure of a Kir3. 1 …
continuous transmembrane and cytosolic portions. A high-resolution structure of a Kir3. 1 …