Genetics of multiple sclerosis: lessons from polygenicity
Large-scale map** studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …
with an increased risk of multiple sclerosis. However, none of these variants are found …
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
Autoimmune liver disease and multiple sclerosis: state of the art and future perspectives
Clinical observations suggest that the prevalence of autoimmune diseases is changing over
time. Both autoimmune liver diseases and multiple sclerosis have shown a significant …
time. Both autoimmune liver diseases and multiple sclerosis have shown a significant …
Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin
Somatic mutations are hypothesized to play a role in many non-neoplastic diseases. We
performed whole-exome sequencing of 1,182 microbiopsies dissected from lesional and …
performed whole-exome sequencing of 1,182 microbiopsies dissected from lesional and …
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
M Bronge, KA Högelin, OG Thomas, S Ruhrmann… - Science …, 2022 - science.org
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in
which pathological T cells, likely autoimmune, play a key role. Despite its central importance …
which pathological T cells, likely autoimmune, play a key role. Despite its central importance …
Polypharmacy in outpatients with relapsing-remitting multiple sclerosis: A single-center study
Background Multiple sclerosis (MS) is an immune-mediated disease of the central nervous
system. Given the chronic and heterogenous nature of the disease, treatment with various …
system. Given the chronic and heterogenous nature of the disease, treatment with various …
Multi-drug use among patients with multiple sclerosis: A cross-sectional study of associations to clinicodemographic factors
Multiple sclerosis (MS) is the most prevalent immune-mediated disease affecting the central
nervous system. A treatment strategy with multiple therapies is a frequent clinical scenario …
nervous system. A treatment strategy with multiple therapies is a frequent clinical scenario …
Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization
G Ma, J Yang, X Wang, E **a, J Yu, M Zhang, Y Hu… - Scientific Reports, 2024 - nature.com
As an autoimmune disease, up to 73% of patients with primary biliary cholangitis (PBC)
have a combination of extrahepatic autoimmune diseases (EHAIDs); however, the causal …
have a combination of extrahepatic autoimmune diseases (EHAIDs); however, the causal …
Association between Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Risk of Autoimmune Diseases: A Systematic Review and Meta‐Analysis
M Lu, K Peng, L Song, L Luo, P Liang… - Disease …, 2022 - Wiley Online Library
Methylenetetrahydrofolate reductase (MTHFR) is a critical rate‐limiting enzyme in the
homocysteine/methionine metabolism pathway that is implicated in the pathogenesis and …
homocysteine/methionine metabolism pathway that is implicated in the pathogenesis and …
Usefulness of clinical and laboratory criteria for diagnosing autoimmune liver disease among patients with systemic lupus erythematosus: an observational study
R Heijke, A Ahmad, M Frodlund, L Wirestam… - Journal of Clinical …, 2021 - mdpi.com
Abnormal liver function tests are frequently observed during follow-up of patients with
systemic lupus erythematosus (SLE) but data on co-existence with autoimmune liver …
systemic lupus erythematosus (SLE) but data on co-existence with autoimmune liver …