Global increasing demand for high life quality and length facilitates the development of
tissue engineering and regenerative medicine, which apply multidisciplinary theories and …

Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Aims Naturally secreted nanovesicles known as exosomes are required for the regenerative
effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in …

Administration of mesenchymal stem cells (MSCs) to diseased hearts improves cardiac
function and reduces scar. These effects occur via stimulation of endogenous repair …

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Heart failure is a global problem with an estimated prevalence of 38 million patients
worldwide, a number that is increasing with the ageing of the population. It is the most …

Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as
therapeutic entities, particularly in stem cell-related approaches, has underlined the need for …

The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy
have been assessed in several clinical trials. These trials can be categorized as those using …

We engineered a microneedle patch integrated with cardiac stromal cells (MN-CSCs) for
therapeutic heart regeneration after acute myocardial infarction (MI). To perform cell-based …