The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

Oxidative stress involves the increased production and accumulation of free radicals,
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …

Aerobic glycolysis, also referred to as the Warburg effect, has been regarded as the
dominant metabolic phenotype in cancer cells for a long time. More recently, it has been …

Abnormal metabolism is a hallmark of cancer, yet its regulation remains poorly understood.
Cancer cells were considered to utilize primarily glycolysis for ATP production, referred to as …

Ferroptotic cancer therapy is promising in many scenarios where traditional cancer
therapies show a poor response. However, certain types of cancers lack the long-chain acyl …

Chronic exposure to arsenic (As) compounds leads to its accumulation in the body, with skin
lesions and cancer being the most typical outcomes. Treating As-induced diseases …

Osteoporosis is characterized by a decline in bone mineral density (BMD) and increased
fracture risk. Free radicals and antioxidant systems play a central role in bone remodeling …

Competing models of mitochondrial energy metabolism in the heart are highly disputed. In
addition, the mechanisms of reactive oxygen species (ROS) production and scavenging are …

Significance: Redox pioneer Helmut Sies attempted to explain reactive species' challenges
faced by organelles, cells, tissues, and organs via three complementary definitions:(i) …

Hydrogen peroxide (H2O2) promotes a range of phenotypes depending on its intracellular
concentration and dosing kinetics, including cell death. While this qualitative relationship …