Why primate models matter

KA Phillips, KL Bales, JP Capitanio… - American journal of …, 2014 - Wiley Online Library
Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …

Functional connectivity of the brain across rodents and humans

N Xu, TJ LaGrow, N Anumba, A Lee, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the
spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is …

Whole-brain comparison of rodent and human brains using spatial transcriptomics

A Beauchamp, Y Yee, BC Darwin, A Raznahan… - elife, 2022 - elifesciences.org
The ever-increasing use of mouse models in preclinical neuroscience research calls for an
improvement in the methods used to translate findings between mouse and human brains …

Cortical folding scales universally with surface area and thickness, not number of neurons

B Mota, S Herculano-Houzel - Science, 2015 - science.org
Larger brains tend to have more folded cortices, but what makes the cortex fold has
remained unknown. We show that the degree of cortical folding scales uniformly across …

The mouse cortical connectome, characterized by an ultra-dense cortical graph, maintains specificity by distinct connectivity profiles

R Gămănuţ, H Kennedy, Z Toroczkai, M Ercsey-Ravasz… - Neuron, 2018 - cell.com
The inter-areal wiring pattern of the mouse cerebral cortex was analyzed in relation to a
refined parcellation of cortical areas. Twenty-seven retrograde tracer injections were made …

[LIVRE][B] The human advantage: a new understanding of how our brain became remarkable

S Herculano-Houzel - 2016 - books.google.com
Why our human brains are awesome, and how we left our cousins, the great apes, behind: a
tale of neurons and calories, and cooking. Humans are awesome. Our brains are gigantic …

Brain scaling in mammalian evolution as a consequence of concerted and mosaic changes in numbers of neurons and average neuronal cell size

S Herculano-Houzel, PR Manger… - Frontiers in neuroanatomy, 2014 - frontiersin.org
Enough species have now been subject to systematic quantitative analysis of the
relationship between the morphology and cellular composition of their brain that patterns …

Neural cognitive signals during spontaneous movements in the macaque

S Tremblay, C Testard, RW DiTullio, J Inchauspé… - Nature …, 2023 - nature.com
The single-neuron basis of cognitive processing in primates has mostly been studied in
laboratory settings where movements are severely restricted. It is unclear, therefore, how …

The elephant brain in numbers

S Herculano-Houzel, K Avelino-de-Souza… - Frontiers in …, 2014 - frontiersin.org
What explains the superior cognitive abilities of the human brain compared to other, larger
brains? Here we investigate the possibility that the human brain has a larger number of …

Opportunities and challenges in modeling human brain disorders in transgenic primates

CG Jennings, R Landman, Y Zhou, J Sharma… - Nature …, 2016 - nature.com
Molecular genetic tools have had a profound impact on neuroscience, but until recently their
application has largely been confined to a few model species, most notably mouse …