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Why primate models matter
Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …
medical and scientific advances of the past century. NHPs are used because of their …
Functional connectivity of the brain across rodents and humans
Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the
spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is …
spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is …
Whole-brain comparison of rodent and human brains using spatial transcriptomics
The ever-increasing use of mouse models in preclinical neuroscience research calls for an
improvement in the methods used to translate findings between mouse and human brains …
improvement in the methods used to translate findings between mouse and human brains …
Cortical folding scales universally with surface area and thickness, not number of neurons
Larger brains tend to have more folded cortices, but what makes the cortex fold has
remained unknown. We show that the degree of cortical folding scales uniformly across …
remained unknown. We show that the degree of cortical folding scales uniformly across …
The mouse cortical connectome, characterized by an ultra-dense cortical graph, maintains specificity by distinct connectivity profiles
The inter-areal wiring pattern of the mouse cerebral cortex was analyzed in relation to a
refined parcellation of cortical areas. Twenty-seven retrograde tracer injections were made …
refined parcellation of cortical areas. Twenty-seven retrograde tracer injections were made …
[LIVRE][B] The human advantage: a new understanding of how our brain became remarkable
S Herculano-Houzel - 2016 - books.google.com
Why our human brains are awesome, and how we left our cousins, the great apes, behind: a
tale of neurons and calories, and cooking. Humans are awesome. Our brains are gigantic …
tale of neurons and calories, and cooking. Humans are awesome. Our brains are gigantic …
Brain scaling in mammalian evolution as a consequence of concerted and mosaic changes in numbers of neurons and average neuronal cell size
Enough species have now been subject to systematic quantitative analysis of the
relationship between the morphology and cellular composition of their brain that patterns …
relationship between the morphology and cellular composition of their brain that patterns …
Neural cognitive signals during spontaneous movements in the macaque
The single-neuron basis of cognitive processing in primates has mostly been studied in
laboratory settings where movements are severely restricted. It is unclear, therefore, how …
laboratory settings where movements are severely restricted. It is unclear, therefore, how …
The elephant brain in numbers
What explains the superior cognitive abilities of the human brain compared to other, larger
brains? Here we investigate the possibility that the human brain has a larger number of …
brains? Here we investigate the possibility that the human brain has a larger number of …
Opportunities and challenges in modeling human brain disorders in transgenic primates
Molecular genetic tools have had a profound impact on neuroscience, but until recently their
application has largely been confined to a few model species, most notably mouse …
application has largely been confined to a few model species, most notably mouse …