Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment
The nonreceptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) integrates
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
Functions of Shp2 in cancer
J Zhang, F Zhang, R Niu - Journal of cellular and molecular …, 2015 - Wiley Online Library
Diagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy
and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug …
and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug …
SHP2 sails from physiology to pathology
M Tajan, A de Rocca Serra, P Valet, T Edouard… - European journal of …, 2015 - Elsevier
Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been …
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been …
Reactive oxygen species and mitochondrial homeostasis as regulators of stem cell fate and function
DQ Tan, T Suda - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: The precise role and impact of reactive oxygen species (ROS) in stem cells,
which are essential for lifelong tissue homeostasis and regeneration, remain of significant …
which are essential for lifelong tissue homeostasis and regeneration, remain of significant …
Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
KP Patel, KJ Newberry, R Luthra… - Blood, The Journal …, 2015 - ashpublications.org
Although most patients with myelofibrosis (MF) derive benefit from ruxolitinib, some are
refractory, have a suboptimal response, or quickly lose their response. To identify genes that …
refractory, have a suboptimal response, or quickly lose their response. To identify genes that …
[PDF][PDF] Shp2 promotes liver cancer stem cell expansion by augmenting β‐catenin signaling and predicts chemotherapeutic response of patients
D ** tissue macrophage populations
R Paccoud, C Saint-Laurent, E Piccolo… - Science Translational …, 2021 - science.org
Insulin resistance is a key event in type 2 diabetes onset and a major comorbidity of obesity.
It results from a combination of fat excess–triggered defects, including lipotoxicity and …
It results from a combination of fat excess–triggered defects, including lipotoxicity and …
Dynamics of thymus function and T cell receptor repertoire breadth in health and disease
T cell recognition of unknown antigens relies on the tremendous diversity of the T cell
receptor (TCR) repertoire; generation of which can only occur in the thymus. TCR repertoire …
receptor (TCR) repertoire; generation of which can only occur in the thymus. TCR repertoire …