The avermectins and milbemycins contain a common macrocyclic lactone (ML) ring, but are
fermentation products of different organisms. The principal structural difference is that …

A key issue in the treatment of many cancers is the development of resistance to
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …

Anthelmintic resistance has a great impact on livestock production systems worldwide, is an
emerging concern in companion animal medicine, and represents a threat to our ongoing …

Anthelmintic resistance in human and animal pathogenic helminths has been spreading in
prevalence and severity. Multidrug resistance is a widespread problem in livestock animals …

Parasitic helminths cause significant disease in animals and humans. In the absence of
alternative treatments, anthelmintics remain the principal agents for their control. Resistance …

Triclabendazole (TCBZ) remains the drug of choice for treating infections of the liver fluke,
Fasciola hepatica in livestock and has become the main drug used to treat human cases of …

In rats we examined the effects of some common excipients on the intestinal absorption of
ganciclovir (GCV), a BCS-III drug and substrate of P-gp, by assessing its in vitro transfer from …

The present work was designed to assess the modulatory effects of sesame oil (SO) and
ascorbic acid (AA) on abamectin (ABM)-induced oxidative stress and altered gene …

P-glycoprotein (P-gp) is a crucial membrane transporter situated on the cell's apical surface,
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …

Although the liver has long been thought to play the major role in drug metabolism, also the
metabolic capacity of the intestine is more and more recognized. In vivo studies eventually …