[HTML][HTML] The developmental biology of kinesins
Kinesins are microtubule-based motor proteins that are well known for their key roles in cell
biological processes ranging from cell division, to intracellular transport of mRNAs, proteins …
biological processes ranging from cell division, to intracellular transport of mRNAs, proteins …
Causes, costs and consequences of kinesin motors communicating through the microtubule lattice
Microtubules are critical for a variety of important functions in eukaryotic cells. During
intracellular trafficking, molecular motor proteins of the kinesin superfamily drive the …
intracellular trafficking, molecular motor proteins of the kinesin superfamily drive the …
CAMSAP1 role in orchestrating structure and dynamics of manchette microtubule minus-ends impacts male fertility during spermiogenesis
W Hu, R Zhang, H Xu, Y Li, X Yang… - Proceedings of the …, 2023 - National Acad Sciences
The manchette is a crucial transient structure involved in sperm development, with its
composition and regulation still not fully understood. This study focused on investigating the …
composition and regulation still not fully understood. This study focused on investigating the …
MKLP2 is a motile kinesin that transports the chromosomal passenger complex during anaphase
IE Adriaans, PJ Hooikaas, A Aher, MJM Vromans… - Current Biology, 2020 - cell.com
During cytokinesis, signals from the anaphase spindle direct the formation and position of a
contractile ring at the cell cortex [1]. The chromosomal passenger complex (CPC) …
contractile ring at the cell cortex [1]. The chromosomal passenger complex (CPC) …
Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells
When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-
driven translocation of the centrosome toward the contact site leads to reorganization of …
driven translocation of the centrosome toward the contact site leads to reorganization of …
[HTML][HTML] Parthenolide destabilizes microtubules by covalently modifying tubulin
Detyrosination of the α-tubulin C-terminal tail is a post-translational modification (PTM) of
microtubules that is key for many biological processes. 1 Although detyrosination is the …
microtubules that is key for many biological processes. 1 Although detyrosination is the …
Ciliary kinesins beyond IFT: cilium length, disassembly, cargo transport and signalling
ML Reilly, A Benmerah - Biology of the Cell, 2019 - Wiley Online Library
Cilia and flagella are microtubule‐based antenna which are highly conserved among
eukaryotes. In vertebrates, primary and motile cilia have evolved to exert several key …
eukaryotes. In vertebrates, primary and motile cilia have evolved to exert several key …
Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
SK Morthorst, ST Christensen… - The FEBS journal, 2018 - Wiley Online Library
Primary cilia are antenna‐like sensory organelles that regulate a substantial number of
cellular signalling pathways in vertebrates, both during embryonic development as well as in …
cellular signalling pathways in vertebrates, both during embryonic development as well as in …
Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A)
Defects in the motor domain of kinesin family member 1A (KIF1A), a neuron‐specific ATP‐
dependent anterograde axonal transporter of synaptic cargo, are well‐recognized to cause …
dependent anterograde axonal transporter of synaptic cargo, are well‐recognized to cause …
Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12–tubulin complex
S Taguchi, J Nakano, T Imasaki, T Kita… - Elife, 2022 - elifesciences.org
Kinesin superfamily proteins are microtubule-based molecular motors driven by the energy
of ATP hydrolysis. Among them, the kinesin-4 family is a unique motor that inhibits …
of ATP hydrolysis. Among them, the kinesin-4 family is a unique motor that inhibits …