MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC).
MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also …

The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism
underlying this remains unclear. In a mouse lung model of KRas G12D-driven adenomas …

Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …

The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a major player in cell cycle control
and it is mainly regulated at the transcriptional level. Whereas induction of p21 …

Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine
groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage …

Promoter hypermethylation preventing expression of the RAS association domain family 1
isoform A (RASSF1A) gene product is among the most abundant epigenetic deregulations in …

Obesity has been recognized as a risk factor for breast cancer. Adipocyte-derived leptin may
play as a paracrine regulator on the growth of breast cancer cells. Expression of both leptin …

Background Programmed cell death-ligand 1 (PD-L1) is overexpressed in tumor cells, which
causes tumor cells to escape T cell killing, and promotes tumor cell survival, cell …

Background Colorectal cancer (CRC) is the most common malignancy of the digestive tract,
and to date, morbidity and mortality rates remain high. While existing therapeutic methods …