Air pollutants deteriorate the survival environment and endanger human health around the
world. A large number of studies have confirmed that air pollution jeopardizes multiple …

Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of
cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work …

Chondrocyte senescence and reduced lubrication play pivotal roles in the pathogenesis of
age‐related osteoarthritis (OA). In the present study, highly lubricated and drug‐loaded …

Mounting evidence indicates that the microbiota, the unique combination of microorganisms
residing in a specific environment, plays an essential role in the development of a wide …

Peroxidasin is a heme-containing peroxidase enzyme that plays a vital role in the cross-
linking of collagen IV molecules in basement membranes. Collagen IV cross-links are …

A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes
in ER breast cancer has been established. However, the mechanisms of tumor induction of …

Purpose: Despite high clinical need, there are no biomarkers that accurately predict the
response of patients with metastatic melanoma to anti-PD-1 therapy. Experimental Design …

Background The immune microenvironment and oxidative stress of melanoma show
significant heterogeneity, which affects tumor growth, invasion and treatment response …

Aim Due to the growing commercialization of titanium dioxide nanoparticles (TNPs), it is
necessary to use these particles in a manner that is safe, healthy and environmental friendly …

Microenvironment and transcriptional plasticity generate subpopulations within the tumor,
and the use of BRAF inhibitors (BRAFis) contributes to the rise and selection of resistant …