Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …

Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors
that regulate lipid and energy metabolism. The brain–gut–liver axis plays an essential role in …

Objective Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma
(HCC) is an increasing healthcare burden worldwide. We examined the role of dietary …

Background Immune checkpoint inhibitors (ICIs) are promising agents for unresectable
hepatocellular carcinoma (uHCC), but lack effective biomarker to predict outcomes. The gut …

Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …

Diverse liver diseases undergo a similar pathophysiological process in which liver
regeneration follows a liver injury. Given the important role of the gut-liver axis in health and …

The polysaccharides from Auricularia auricula (AAPs), containing a large number of O-acetyl
groups that are related to the physiological and biological properties, seem to be potential …

Cardiovascular disease (CVD) is the leading cause of death in the United States. For years,
dietary cholesterol was implicated in increasing blood cholesterol levels leading to the …

Given that obesity and associated disorder type II diabetes mellitus have reached epidemic
proportions worldwide, the development of efficient prevention and therapeutic interventions …

Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1. 14) is the first and rate-limiting
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …