RNA-based therapeutics: from antisense oligonucleotides to miRNAs
The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …
Current status of microRNA-based therapeutic approaches in neurodegenerative disorders
S Paul, LA Bravo Vázquez, S Pérez Uribe… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …
mirDIP 4.1—integrative database of human microRNA target predictions
MicroRNAs are important regulators of gene expression, achieved by binding to the gene to
be regulated. Even with modern high-throughput technologies, it is laborious and expensive …
be regulated. Even with modern high-throughput technologies, it is laborious and expensive …
PseUI: Pseudouridine sites identification based on RNA sequence information
J He, T Fang, Z Zhang, B Huang, X Zhu, Y **ong - BMC bioinformatics, 2018 - Springer
Background Pseudouridylation is the most prevalent type of posttranscriptional modification
in various stable RNAs of all organisms, which significantly affects many cellular processes …
in various stable RNAs of all organisms, which significantly affects many cellular processes …
The dual regulatory role of MiR-181a in breast cancer
MicroRNAs (miRNAs) are a family of highly conserved noncoding single˗ stranded RNA
molecules of 21 to 25 nucleotides. miRNAs silence their cognate target genes at the post …
molecules of 21 to 25 nucleotides. miRNAs silence their cognate target genes at the post …
Candida albicans induces cross-kingdom miRNA trafficking in human monocytes to promote fungal growth
LD Halder, S Babych, DI Palme… - MBio, 2022 - Am Soc Microbiol
In response to infections, human immune cells release extracellular vesicles (EVs) that carry
a situationally adapted cocktail of proteins and nucleic acids, including microRNAs …
a situationally adapted cocktail of proteins and nucleic acids, including microRNAs …
Dysregulation of MiR-144-5p/RNF187 axis contributes to the progression of colorectal cancer
Z Gao, J Jiang, L Hou, B Zhang - Journal of translational internal …, 2022 - degruyter.com
Background and Objectives RING finger protein 187 (RNF187) belongs to RING domain-
containing E3 ligases family, which was recently reported to be involved in oncogenesis and …
containing E3 ligases family, which was recently reported to be involved in oncogenesis and …
Onco-miR-21 promotes Stat3-dependent gastric cancer progression
J Tse, T Pierce, ALE Carli, MG Alorro, S Thiem… - Cancers, 2022 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are a class of highly conserved small, non-protein
coding RNAs with often-deregulated expression in cancer. miR-21 is a well-studied cancer …
coding RNAs with often-deregulated expression in cancer. miR-21 is a well-studied cancer …
What's the target: understanding two decades of in silico microRNA-target prediction
Motivation Since the initial discovery of microRNAs as post-transcriptional, regulatory key
players in the 1990s, a total number of mature microRNAs have been publicly described for …
players in the 1990s, a total number of mature microRNAs have been publicly described for …
Evolutionary dynamics of microRNA target sites across vertebrate evolution
MicroRNAs (miRNAs) control the abundance of the majority of the vertebrate transcriptome.
The recognition sequences, or target sites, for bilaterian miRNAs are found predominantly in …
The recognition sequences, or target sites, for bilaterian miRNAs are found predominantly in …