The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …

Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is
phosphorylated to form sphingosine-1-phosphate (S1P). Ceramide, SPH, and S1P are …

In familial pulmonary arterial hypertension (FPAH), the autosomal dominant disease-
causing BMPR2 mutation is only 20% penetrant, suggesting that genetic variation provides …

The FERM-like domain–containing sorting nexins of the SNX17/SNX27/SNX31 family have
been proposed to mediate retrieval of transmembrane proteins from the lysosomal pathway …

The low‐density lipoprotein (LDL) receptor related protein (LRP1 or LRP) is a large
endocytic receptor widely expressed in several tissues and known to play roles in areas as …

After peripheral nerve injury, Schwann cells are released from the degenerating nerve,
dedifferentiated, and then actively participate in axonal regeneration. Dedifferentiated …

The extracellular matrix (ECM) is a biological substrate composed of collagens,
proteoglycans and glycoproteins that ensures proper cell migration and adhesion and keeps …

In Helicobacter pylori infection, vacuolating cytotoxin (VacA)-induced mitochondrial damage
leading to apoptosis is believed to be a major cause of cell death. It has also been proposed …

Low-density lipoprotein receptor–related protein-1 (LRP1) is a large endocytic and signaling
receptor that is widely expressed. In the liver, LRP1 plays an important role in regulating the …

Integrins are heterodimeric cell surface receptors composed of α and β subunits that control
adhesion, proliferation and gene expression. The integrin heterodimer binding to ligand …