Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
Childhood adversity and neural development: A systematic review
An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …
Post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) occurs in 5–10% of the population and is twice as
common in women as in men. Although trauma exposure is the precipitating event for PTSD …
common in women as in men. Although trauma exposure is the precipitating event for PTSD …
[HTML][HTML] Anxiety cells in a hippocampal-hypothalamic circuit
The hippocampus is traditionally thought to transmit contextual information to limbic
structures where it acquires valence. Using freely moving calcium imaging and …
structures where it acquires valence. Using freely moving calcium imaging and …
A conceptual framework for the neurobiological study of resilience
R Kalisch, MB Müller, O Tüscher - Behavioral and brain sciences, 2015 - cambridge.org
The well-replicated observation that many people maintain mental health despite exposure
to severe psychological or physical adversity has ignited interest in the mechanisms that …
to severe psychological or physical adversity has ignited interest in the mechanisms that …
Fear generalization and anxiety: behavioral and neural mechanisms
Fear can be an adaptive emotion that helps defend against potential danger. Classical
conditioning models elegantly describe how animals learn which stimuli in the environment …
conditioning models elegantly describe how animals learn which stimuli in the environment …
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the
cellular stress response. In contrast, it is unclear if the PACAP–PAC1 receptor pathway has …
cellular stress response. In contrast, it is unclear if the PACAP–PAC1 receptor pathway has …
Context processing and the neurobiology of post-traumatic stress disorder
I Liberzon, JL Abelson - Neuron, 2016 - cell.com
Progress in clinical and affective neuroscience is redefining psychiatric illness as
symptomatic expression of cellular/molecular dysfunctions in specific brain circuits. Post …
symptomatic expression of cellular/molecular dysfunctions in specific brain circuits. Post …
From Pavlov to PTSD: the extinction of conditioned fear in rodents, humans, and anxiety disorders
MB VanElzakker, MK Dahlgren, FC Davis… - Neurobiology of learning …, 2014 - Elsevier
Abstract Nearly 100 years ago, Ivan Pavlov demonstrated that dogs could learn to use a
neutral cue to predict a biologically relevant event: after repeated predictive pairings …
neutral cue to predict a biologically relevant event: after repeated predictive pairings …
Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders
Although an influence of adult neurogenesis in mediating some of the effects of
antidepressants has received considerable attention in recent years, much less is known …
antidepressants has received considerable attention in recent years, much less is known …