PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies

R Thapa, G Gupta, AA Bhat, WH Almalki… - International journal of …, 2023 - Elsevier
The intricate molecular pathways governing cancer development and progression have
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …

[HTML][HTML] Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

S Lorzadeh, L Kohan, S Ghavami, N Azarpira - Biochimica et Biophysica …, 2021 - Elsevier
Cellular homeostasis and adaptation to various environmental conditions are importantly
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …

Signal transduction pathways in breast cancer: the important role of PI3K/Akt/mTOR

MA Ortega, O Fraile-Martínez, Á Asúnsolo… - Journal of …, 2020 - Wiley Online Library
Breast cancer is the cancer with the highest prevalence in women and is the number‐one
cause of cancer mortality worldwide. Cell transduction is a fundamental process in the …