Abnormalities in the Wnt signalling pathway are found in a wide range of cancers. The
diverse origin of these malignancies implies that the contribution that disrupted Wnt …

No longer considered to be exclusive to cellular developmental pathways, the Wnt family of
secreted cysteine-rich glycosylated proteins has emerged as versatile targets for a variety of …

Genetic studies in humans and mice have revealed an important role of the Wnt signaling
pathway in the regulation of bone mass, resulting from potent effects on the control of …

In slightly over a period of twenty years, our comprehension of the cellular and molecular
mechanisms that govern the Wnt signaling pathway continue to unfold. The Wnt proteins …

Epithelial-mesenchymal transition (EMT) is a key event in the generation of invasive tumor
cells. A hallmark of EMT is the repression of E-cadherin expression, which is regulated by …

In both physiological and cell culture systems, EGF-stimulated ERK activity occurs in
discrete pulses within individual cells. Many feedback loops are present in the EGF receptor …

Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment
of cell fates and proper tissue patterning during embryo development and for the regulation …

The Wnt/β-catenin signaling pathway is tightly regulated and has important functions in
development, tissue homeostasis, and regeneration. Deregulation of Wnt/β-catenin …

Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D
(cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal …

Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important
role in G1-S phase progression. The human cyclin D1 promoter contains multiple …