Ferroptosis, necroptosis, and pyroptosis in gastrointestinal cancers: the chief culprits of tumor progression and drug resistance

X Zhu, S Li - Advanced Science, 2023 - Wiley Online Library
In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the
younger population. Effective treatment is crucial for improving patients' survival outcomes …

Ferroptosis: cancer stem cells rely on iron until “to die for” it

E Cosialls, R El Hage, L Dos Santos, C Gong… - Cells, 2021 - mdpi.com
Cancer stem cells (CSCs) are a distinct subpopulation of tumor cells with stem cell-like
features. Able to initiate and sustain tumor growth and mostly resistant to anti-cancer …

[HTML][HTML] Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells

R Wei, Y Zhao, J Wang, X Yang, S Li… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Rationale: Colorectal cancer (CRC) is a common malignant tumor of the digestive system.
However, the efficacy of surgery and chemotherapy is limited. Ferroptosis is an iron-and …

Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1–Wnt/β‐catenin–TFE3 feedback loop …

Y Luo, S Huang, J Wei, H Zhou, W Wang… - Clinical and …, 2022 - Wiley Online Library
Background Ferroptosis is principally caused by iron catalytic activity and intracellular lipid
peroxidation. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis …

Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis

X Xu, X Zhang, C Wei, D Zheng, X Lu, Y Yang… - European Journal of …, 2020 - Elsevier
Recent studies have revealed the critical roles of ferroptosis in different physiological and
pathological processes, however, its effects on the progression of colorectal cancer stem …

HO‐1 contributes to luteolin‐triggered ferroptosis in clear cell renal cell carcinoma via increasing the labile iron pool and promoting lipid peroxidation

S Han, F Lin, Y Qi, C Liu, L Zhou, Y **a… - Oxidative Medicine …, 2022 - Wiley Online Library
Ferroptosis, a novel form of regulated cell death characterized by disrupted iron metabolism
and the accumulation of lipid peroxides, has exhibited enormous potential in the therapy of …

Association of oral dysbiosis with oral cancer development

GRM La Rosa, G Gattuso, E Pedullà… - Oncology …, 2020 - spandidos-publications.com
Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer.
Numerous risk factors mainly related to unhealthy habits and responsible for chronic …

Toward improved human health: Nrf2 plays a critical role in regulating ferroptosis

J Lu, Y Zhao, M Liu, J Lu, S Guan - Food & Function, 2021 - pubs.rsc.org
Ferroptosis is a recently defined type of regulated cell death caused by an excess iron-
dependent accumulation of lipid peroxides and is morphologically and biochemically distinct …

[Retracted] Ferroptosis‐Related Long Noncoding RNAs as Prognostic Marker for Colon Adenocarcinoma

Y Qiu, H Li, Q Zhang, X Qiao… - Applied Bionics and …, 2022 - Wiley Online Library
Background. The incidence of colon adenocarcinoma (COAD) has been increasing over
time. Although ferroptosis and long noncoding RNAs (lncRNAs) have been extensively …

Emerging mechanisms and disease implications of ferroptosis: potential applications of natural products

C Ge, S Zhang, H Mu, S Zheng, Z Tan… - Frontiers in Cell and …, 2022 - frontiersin.org
Ferroptosis, a newly discovered form of regulatory cell death (RCD), has been demonstrated
to be distinct from other types of RCD, such as apoptosis, necroptosis, and autophagy …