Microbial tryptophan catabolites in health and disease
Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …
Implication of intestinal barrier dysfunction in gut dysbiosis and diseases
The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …
[HTML][HTML] Understanding the holobiont: how microbial metabolites affect human health and shape the immune system
The human gastrointestinal tract is populated by a diverse, highly mutualistic microbial flora,
which is known as the microbiome. Disruptions to the microbiome have been shown to be …
which is known as the microbiome. Disruptions to the microbiome have been shown to be …
[HTML][HTML] Metabolite interactions between host and microbiota during health and disease: Which feeds the other?
Y Zhang, R Chen, DD Zhang, S Qi, Y Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …
develop and remain healthy. Most of these metabolites are produced by microbiota and …
The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases
Y Zhou, Y Chen, H He, M Peng, M Zeng, H Sun - Neuropharmacology, 2023 - Elsevier
At present, a large number of relevant studies have suggested that the changes in gut
microbiota are related to the course of nervous system diseases, and the microbiota-gut …
microbiota are related to the course of nervous system diseases, and the microbiota-gut …
The pregnane X receptor and indole-3-propionic acid shape the intestinal mesenchyme to restrain inflammation and fibrosis
KL Flannigan, KM Nieves, HE Szczepanski… - Cellular and molecular …, 2023 - Elsevier
Background & Aims Fibrosis is a common complication of inflammatory bowel diseases
(IBDs). The pregnane X receptor (PXR)(encoded by NR1I2) suppresses intestinal …
(IBDs). The pregnane X receptor (PXR)(encoded by NR1I2) suppresses intestinal …
Targeting dietary and microbial tryptophan-indole metabolism as therapeutic approaches to colon cancer
M Wyatt, KL Greathouse - Nutrients, 2021 - mdpi.com
Tryptophan metabolism, via the kynurenine (Kyn) pathway, and microbial transformation of
tryptophan to indolic compounds are fundamental for host health; both of which are altered …
tryptophan to indolic compounds are fundamental for host health; both of which are altered …
[HTML][HTML] The “gut feeling”: breaking down the role of gut microbiome in multiple sclerosis
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system
with unknown etiology. Recently, the gut microbiota has emerged as a potential factor in the …
with unknown etiology. Recently, the gut microbiota has emerged as a potential factor in the …
Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative …
Hyperglycaemia is a major contributor to diabetic cardiovascular disease with
hyperglycaemia-induced endothelial dysfunction recognized as the initiating cause …
hyperglycaemia-induced endothelial dysfunction recognized as the initiating cause …
Skatole: A thin red line between its benefits and toxicity
E Zgarbová, R Vrzal - Biochimie, 2023 - Elsevier
Abstract Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of
vertebrates and is produced by certain flowers. Skatole has been used in specific products …
vertebrates and is produced by certain flowers. Skatole has been used in specific products …