The view of organelles and how they operate together has changed dramatically over the
last two decades. The textbook view of organelles was that they operated largely …

The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane
biogenesis that rely on lipid exchange via membrane contact sites,–, but the underpinning …

The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …

Chorea-acanthocytosis (ChAc) and McLeod syndrome are diseases with shared clinical
manifestations caused by mutations in VPS13A and XK, respectively. Key features of these …

Two years on from the initial release of AlphaFold, we have seen its widespread adoption as
a structure prediction tool. Here, we discuss some of the latest work based on AlphaFold …

Mutations in VPS13C cause early-onset, autosomal recessive Parkinson's disease (PD). We
have established that VPS13C encodes a lipid transfer protein localized to contact sites …

The Endoplasmic Reticulum (ER) is an endomembrane system that plays a multiplicity of
roles in cell physiology and populates even the most distal cell compartments, including …

Junctions between the endoplasmic reticulum (ER) and the outer membrane of the nuclear
envelope (NE) physically connect both organelles. These ER–NE junctions are essential for …

Lipid transfer between organelles requires proteins that shield the hydrophobic portions of
lipids as they cross the cytoplasm. In the last decade a new structural form of lipid transfer …