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Organ-on-a-chip platforms integrated with biosensors for precise monitoring of the cells and cellular microenvironment
W Yang, T Li, S Liao, J Zhou, L Huang - TrAC Trends in Analytical …, 2024 - Elsevier
Abstract Organs-on-chips (OoCs) are in vitro models that simulate the anatomical and
physiological structure of human organs at the micro-scale level. With the advantages of …
physiological structure of human organs at the micro-scale level. With the advantages of …
In situ biosensing technologies for an organ-on-a-chip
The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges
accompanying in vivo experiments. Organoids and organs-on-chips have been developed …
accompanying in vivo experiments. Organoids and organs-on-chips have been developed …
Critical suitability evaluation of caco-2 cells for gut-on-a-chip
Currently, culturing Caco-2 cells in a Gut-on-a-chip (GOC) is well-accepted for develo**
intestinal disease models and drug screening. However, Caco-2 cells were found to …
intestinal disease models and drug screening. However, Caco-2 cells were found to …
[HTML][HTML] Piezo1 in digestive system function and dysfunction
J He, X **e, Z **ao, W Qian, L Zhang… - International Journal of …, 2023 - mdpi.com
Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely
expressed in the digestive system and participates in biological functions physiologically …
expressed in the digestive system and participates in biological functions physiologically …
[HTML][HTML] Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology
Traditional drug development is a long and expensive process with high rates of failure. This
has prompted the pharmaceutical industry to seek more efficient drug development …
has prompted the pharmaceutical industry to seek more efficient drug development …
Gut-on-a-chip research for drug development: implications of chip design on preclinical oral bioavailability or intestinal disease studies
The gut plays a key role in drug absorption and metabolism of orally ingested drugs.
Additionally, the characterization of intestinal disease processes is increasingly gaining …
Additionally, the characterization of intestinal disease processes is increasingly gaining …
Direct effects of toxic divalent cations on contractile proteins with implications for the heart: unraveling mechanisms of dysfunction
The binding of calcium and magnesium ions to proteins is crucial for regulating heart
contraction. However, other divalent cations, including xenobiotics, can accumulate in the …
contraction. However, other divalent cations, including xenobiotics, can accumulate in the …
The synergy between deep learning and organs-on-chips for high-throughput drug screening: a review
Organs-on-chips (OoCs) are miniature microfluidic systems that have arguably become a
class of advanced in vitro models. Deep learning, as an emerging topic in machine learning …
class of advanced in vitro models. Deep learning, as an emerging topic in machine learning …
Getting closer to modeling the gut-brain axis using induced pluripotent stem cells
The gut microbiome (GM), the gut barrier, and the blood-brain barrier (BBB) are key
elements of the gut-brain axis (GBA). The advances in organ-on-a-chip and induced …
elements of the gut-brain axis (GBA). The advances in organ-on-a-chip and induced …
[HTML][HTML] Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques
H Wang, X Li, P Shi, X You, G Zhao - Materials Today Bio, 2024 - Elsevier
As a booming engineering technology, the microfluidic chip has been widely applied for
replicating the complexity of human intestinal micro-physiological ecosystems in vitro …
replicating the complexity of human intestinal micro-physiological ecosystems in vitro …