Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Background Although research productivity in the field of frailty has risen exponentially in
recent years, there remains a lack of consensus regarding the measurement of this …

The International Conference on Harmonization considers older people a 'special
population', as they differ from younger adults in terms of comorbidity, polypharmacy …

Aging involves progressive impairments in the functional reserve of multiple organs, which
might also affect drug metabolism and pharmacokinetics. In addition, the elderly population …

The rising of global geriatric population has contributed to increased prevalence of
dementia. Dementia is a neurodegenerative disease, which is characterized by progressive …

Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors,
leading to a higher risk of negative health-related outcomes.“Inflammaging”, an age-related …

In develo** and validating the concept of frailty as a geriatric syndrome, it has been
necessary to distinguish the clinical expression of frailty from normal age-related changes …

Ageing is characterized by a progressive decline in the functional reserve of multiple organs
and systems, which can influence drug disposition. In addition, comorbidity and …

Abstract Background Butyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the
liver. Its serum level decreases in many clinical conditions such as acute and chronic liver …

Purpose While some people remain fit and active as they grow older, others experience
complex problems: disease, dependency and disability. Frailty is a term used to describe …