The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Endometriosis is the presence of endometrial tissue outside the uterine cavity usually in the
ovaries, fallopian tube, and pelvic cavity. It's a chronic enigmatic gynecological condition …

The circadian timing system synchronizes cellular function by coordinating rhythmic
transcription via a transcription-translational feedback loop. How the circadian system …

As a substrate and major effector of the mammalian target of rapamycin complex 1
(mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been …

The mechanistic target of rapamycin (mTOR) is a master regulator of protein translation,
metabolism, cell growth and proliferation. It forms two complexes, mTOR complex 1 …

Mammalian target of rapamycin (mTOR) is a major intersection that connects signals from
the extracellular milieu to corresponding changes in intracellular processes. When …

Breast cancer is a highly heterogeneous disease. Tamoxifen is a selective estrogen receptor
(ER) modulator and is mainly indicated for the treatment of breast cancer in postmenopausal …

Background Estrogen plays a critical role in breast cancer (BC) progression through
estrogen receptor (ER)-mediated gene regulation. Emerging studies suggest that the …

The latest and newest discoveries for advanced and metastatic hormone receptor-positive
(HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer are …

Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) is a frequent
event in breast cancer and current efforts are aimed at targeting the mTORC1 signaling …