Structural and functional diversity of type IV secretion systems

TRD Costa, JB Patkowski, K Macé, PJ Christie… - Nature Reviews …, 2024 - nature.com
Considerable progress has been made in recent years in the structural and molecular
biology of type IV secretion systems in Gram-negative bacteria. The latest advances have …

[HTML][HTML] Legionella pneumophila: The Journey from the Environment to the Blood

V Iliadi, J Staykova, S Iliadis, I Konstantinidou… - Journal of Clinical …, 2022 - mdpi.com
An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of
the American Legion was the first time that Legionella spp. was identified. Thereafter, the …

Nitric oxide signaling through three receptors regulates virulence, biofilm formation, and phenotypic heterogeneity of Legionella pneumophila

S Michaelis, T Chen, C Schmid, H Hilbi - MBio, 2024 - journals.asm.org
The causative agent of Legionnaires' disease, Legionella pneumophila, is an environmental
bacterium, that replicates in macrophages, parasitizes amoeba, and forms biofilms. L …

Small molecule communication of Legionella: the ins and outs of autoinducer and nitric oxide signaling

S Michaelis, L Gomez-Valero, T Chen… - Microbiology and …, 2024 - journals.asm.org
Legionella pneumophila is a Gram-negative environmental bacterium, which survives in
planktonic form, colonizes biofilms, and infects protozoa. Upon inhalation of Legionella …

Protein sociology of ProA, Mip and other secreted virulence factors at the Legionella pneumophila surface

L Scheithauer, MS Karagöz, BE Mayer… - Frontiers in Cellular and …, 2023 - frontiersin.org
The pathogenicity of L. pneumophila, the causative agent of Legionnaires' disease, depends
on an arsenal of interacting proteins. Here we describe how surface-associated and …

The large GTPase Sey1/atlastin mediates lipid droplet-and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila

D Hüsler, P Stauffer, B Keller, D Böck, T Steiner… - Elife, 2023 - elifesciences.org
The amoeba-resistant bacterium Legionella pneumophila causes Legionnaires' disease
and employs a type IV secretion system (T4SS) to replicate in the unique, ER-associated …

Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors

DT Patel, PJ Stogios, L Jaroszewski… - Molecular Systems …, 2025 - embopress.org
Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds
of effector proteins inside eukaryotic cells to ensure intracellular replication. Our …

Tap** lipid droplets: A rich fat diet of intracellular bacterial pathogens

D Hüsler, P Stauffer, H Hilbi - Molecular microbiology, 2023 - Wiley Online Library
Lipid droplets (LDs) are dynamic and versatile organelles present in most eukaryotic cells.
LDs consist of a hydrophobic core of neutral lipids, a phospholipid monolayer coat, and a …

The Legionella autoinducer LAI-1 is delivered by outer membrane vesicles to promote interbacterial and interkingdom signaling

M Fan, P Kiefer, P Charki, C Hedberg, J Seibel… - Journal of Biological …, 2023 - jbc.org
Legionella pneumophila is an environmental bacterium, which replicates in amoeba but
also in macrophages, and causes a life-threatening pneumonia called Legionnaires' …