Hyaluronidases are enzymes that degrade hyaluronic acid, which constitutes an essential
part of the extracellular matrix. Initially discovered in bacteria, hyaluronidases are known to …

In the past years, the management of diabetic retinopathy (DR) relied primarily on a good
systemic control of diabetes mellitus, and as soon as the severity of the vascular lesions …

BACKGROUND Most of the complications associated with hyaluronic acid (HA) fillers can be
addressed by hyaluronidase. Extensive experience with this enzyme was accumulated in …

Importance Vascular endothelial growth factor plays a role in proliferative diabetic
retinopathy (PDR). Intravitreal injection of saline has been shown potentially to lead to …

Vitreous hemorrhage is associated with a myriad of conditions such as proliferative diabetic
retinopathy, proliferative retinopathy following vascular occlusion and vasculitis, trauma …

Hyaluronan (HA) is a naturally occurring polysaccharide and well known for its exceptional
properties such as high biocompatibility and biodegradability, along with a low …

Idiopathic epiretinal membranes (iERMs) are fibrocellular sheets of tissue that develop at the
vitreoretinal interface. The iERMs consist of cells and an extracellular matrix (ECM) formed …

Periorbital rejuvenation with neurotoxins and dermal fillers address several aging changes.
Safe and effective results require a thorough understanding of periorbital anatomy, proper …

Diabetic macular edema (DME) is the most common cause of visual deterioration in patients
affected by diabetes mellitus. Grid and focal laser photocoagulation, according to the …

purpose. Microplasmin is a recombinant protein limited to the enzymatic moiety of plasmin
without any of its cringle domains. Its enzymatic activity is similar to that of plasmin enzyme …