Deep learning in cancer pathology: a new generation of clinical biomarkers
Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers.
However, the growing number of these complex biomarkers tends to increase the cost and …
However, the growing number of these complex biomarkers tends to increase the cost and …
5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future
Fluorouracil (5-FU) is an essential component of systemic chemotherapy for colorectal
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …
Colorectal cancer
E Dekker, PJ Tanis, JLA Vleugels, PM Kasi… - The Lancet, 2019 - thelancet.com
Several decades ago, colorectal cancer was infrequently diagnosed. Nowadays, it is the
world's fourth most deadly cancer with almost 900 000 deaths annually. Besides an ageing …
world's fourth most deadly cancer with almost 900 000 deaths annually. Besides an ageing …
Robotic versus laparoscopic surgery for middle and low rectal cancer (REAL): short-term outcomes of a multicentre randomised controlled trial
Q Feng, W Yuan, T Li, B Tang, B Jia, Y Zhou… - The lancet …, 2022 - thelancet.com
Background Robotic surgery for rectal cancer is gaining popularity, but evidence on long-
term oncological outcomes is scarce. We aimed to compare surgical quality and long-term …
term oncological outcomes is scarce. We aimed to compare surgical quality and long-term …
Analysis of plasma cell-free DNA by ultradeep sequencing in patients with stages I to III colorectal cancer
T Reinert, TV Henriksen, E Christensen… - JAMA …, 2019 - jamanetwork.com
Importance Novel sensitive methods for detection and monitoring of residual disease can
improve postoperative risk stratification with implications for patient selection for adjuvant …
improve postoperative risk stratification with implications for patient selection for adjuvant …
The American society of colon and rectal surgeons clinical practice guidelines for the management of rectal cancer
The American Society of Colon and Rectal Surgeons (ASCRS) is dedicated to ensuring high-
quality patient care by advancing the science, prevention, and management of disorders …
quality patient care by advancing the science, prevention, and management of disorders …
Neoadjuvant (chemo) radiotherapy with total mesorectal excision only is not sufficient to prevent lateral local recurrence in enlarged nodes: results of the multicenter …
Purpose Improvements in magnetic resonance imaging (MRI), total mesorectal excision
(TME) surgery, and the use of (chemo) radiotherapy ([C] RT) have improved local control of …
(TME) surgery, and the use of (chemo) radiotherapy ([C] RT) have improved local control of …
International consensus recommendations on key outcome measures for organ preservation after (chemo) radiotherapy in patients with rectal cancer
Multimodal treatment strategies for patients with rectal cancer are increasingly including the
possibility of organ preservation, through nonoperative management or local excision …
possibility of organ preservation, through nonoperative management or local excision …
The multidisciplinary management of rectal cancer
Rectal cancer treatment has evolved during the past 40 years with the use of a standardized
surgical technique for tumour resection: total mesorectal excision. A dramatic reduction in …
surgical technique for tumour resection: total mesorectal excision. A dramatic reduction in …
Neoadjuvant chemoradiotherapy with radiation dose escalation with contact x-ray brachytherapy boost or external beam radiotherapy boost for organ preservation in …
JP Gerard, N Barbet, R Schiappa, N Magné… - The Lancet …, 2023 - thelancet.com
Background Organ preservation after reaching clinical complete response on neoadjuvant
therapy is gaining interest for rectal cancers, although the role of radiation dose escalation is …
therapy is gaining interest for rectal cancers, although the role of radiation dose escalation is …