Most tooth‐bearing non‐mammalian vertebrates have the capacity to replace their teeth
throughout life. This capacity was lost in mammals, which replace their teeth only once at …

Craniomaxillofacial developmental anomalies are one of the most prevalent congenital
defects worldwide and could result from any disruption of normal development processes …

Cis-regulatory changes are thought to play a major role in adaptation. Threespine
sticklebacks have repeatedly colonized freshwater habitats in the Northern Hemisphere …

Sharks and their relatives are typically covered in highly specialized epithelial appendages
embedded in the skin called dermal denticles; ancient tooth-like units (odontodes) …

Mutations in enhancers have been shown to often underlie natural variation but the evolved
differences in enhancer activity can be difficult to identify in vivo. Threespine sticklebacks …

Background Sturgeons belong to an early‐branching lineage often used as a proxy of
ancestor‐like traits of ray‐finned fishes. However, many features of this lineage, such as the …

Pelvic fins are a characteristic structure of the vertebrate Bauplan. Yet, pelvic fin loss has
occurred repeatedly across a wide diversity of other lineages of tetrapods and at least 48 …

The molecular control of tooth development is different between the maxilla and mandible,
contributing to different tooth shapes and locations; however, whether this difference occurs …

Abstract Development and regeneration are orchestrated by gene regulatory networks that
operate in part through transcriptional enhancers. Although many enhancers are pleiotropic …

Most vertebrate species undergo tooth replacement throughout adult life. This process is
marked by the shedding of existing teeth and the regeneration of tooth organs. However …